TY - JOUR
T1 - Endothelial progenitor cells
T2 - Functions and clinical application in cardiac and vascular diseases
AU - Huang, Ya Li
AU - Wang, Yan
AU - Lu, Tong
PY - 2010/5/20
Y1 - 2010/5/20
N2 - Circulating endothelial progenitor cells (EPCs) derived from bone marrow are capable of endocrine, reendothelialization of injured blood vessels and neovascularization of ischemic lesions; besides, they also play a major role in the pathogenesis of atherosclerosis. However, the number and functions of circulating EPCs are greatly declined in patients suffering from cardiovascular diseases. Functions of EPCs are associated with not only pathophysiological factors such as aging, hypertension, diabetes and hyperlipidemia, but also personal lifestyle such as exercise, body weight and smoking, which directly influence the development of cardiovascular diseases. In this review, we mainly focus on the relationship between EPCs and cardiovascular risk factors and the potential roles of EPC therapy for cardiovascular diseases.
AB - Circulating endothelial progenitor cells (EPCs) derived from bone marrow are capable of endocrine, reendothelialization of injured blood vessels and neovascularization of ischemic lesions; besides, they also play a major role in the pathogenesis of atherosclerosis. However, the number and functions of circulating EPCs are greatly declined in patients suffering from cardiovascular diseases. Functions of EPCs are associated with not only pathophysiological factors such as aging, hypertension, diabetes and hyperlipidemia, but also personal lifestyle such as exercise, body weight and smoking, which directly influence the development of cardiovascular diseases. In this review, we mainly focus on the relationship between EPCs and cardiovascular risk factors and the potential roles of EPC therapy for cardiovascular diseases.
KW - Cardiovascular diseases
KW - Endothelial progenitor cells
KW - Risk factors
KW - Therapeutic uses
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U2 - 10.3724/SP.J.1008.2010.00545
DO - 10.3724/SP.J.1008.2010.00545
M3 - Review article
AN - SCOPUS:77953278561
SN - 0258-879X
VL - 31
SP - 545
EP - 548
JO - Academic Journal of Second Military Medical University
JF - Academic Journal of Second Military Medical University
IS - 5
ER -