Endothelial function as a functional expression of cardiovascular risk factors

Martin K. Reriani, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Traditional cardiovascular risk (CV) factors based on the Framingham study have been used to estimate the risk of CV events and determine target cholesterol levels for primary prevention. Recently published systematic reviews have, however, demonstrated that the Framingham risk score is limited in certain cohorts and requires adjustment. Indeed, traditional CV risk factors fail to predict the development of coronary heart disease in 25-50% of cases. This underscores the complex interplay between traditional CV risk factors, genetic predisposition and other atheroprotective factors present in individuals of different populations in predicting CV events. Endothelial dysfunction, a functional expression of the inherent atherosclerotic risk representing an integrated index of both the overall CV risk-factor burden and the sum of all vasculoprotective factors in an individual, may serve as the missing link between CV risk factors and atherosclerotic disease. Endothelial function measurements may aid in future prediction of CV events and help identify high-risk patients for targeted therapy as well as provide a primary therapeutic end point for clinical follow-up of these patients. Recently introduced reactive hyperemia peripheral arterial tonometry is emerging as a promising tool in endothelial function measurement and CV risk stratification.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalBiomarkers in Medicine
Volume4
Issue number3
DOIs
StatePublished - Jun 2010

Fingerprint

Hyperemia
Manometry
Primary Prevention
Genetic Predisposition to Disease
Coronary Disease
Cholesterol
Therapeutics
Population

Keywords

  • Atherosclerosis
  • Endothelial dysfunction
  • Endothelium
  • Surrogate marker
  • Therapeutic end point
  • Vascular health

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

Endothelial function as a functional expression of cardiovascular risk factors. / Reriani, Martin K.; Lerman, Lilach O; Lerman, Amir.

In: Biomarkers in Medicine, Vol. 4, No. 3, 06.2010, p. 351-360.

Research output: Contribution to journalArticle

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