TY - JOUR
T1 - Endothelial function and dysfunction. Part I
T2 - Methodological issues for assessment in the different vascular beds: A statement by the working group on endothelin and endothelial factors of the European society of hypertension
AU - Deanfield, John
AU - Donald, Ann
AU - Ferri, Claudio
AU - Giannattasio, Cristina
AU - Halcox, Julian
AU - Halligan, Sean
AU - Lerman, Amir
AU - Mancia, Giuseppe
AU - Oliver, James J.
AU - Pessina, Achille C.
AU - Rizzoni, Damiano
AU - Rossi, Gian Paolo
AU - Salvetti, Antonio
AU - Schiffrin, Ernesto L.
AU - Taddei, Stefano
AU - Webb, David J.
PY - 2005/1
Y1 - 2005/1
N2 - An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, molecular genetic tests and invasive and non-invasive tools with and without pharmacological and physiological stimuli have been introduced. Furthermore newer pharmacological tools have been proposed. However, the application of these methodologies should fulfil a number of requirements in order to provide conclusive answers in this area of research. Thus, the most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper.
AB - An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, molecular genetic tests and invasive and non-invasive tools with and without pharmacological and physiological stimuli have been introduced. Furthermore newer pharmacological tools have been proposed. However, the application of these methodologies should fulfil a number of requirements in order to provide conclusive answers in this area of research. Thus, the most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper.
UR - http://www.scopus.com/inward/record.url?scp=19944430327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944430327&partnerID=8YFLogxK
U2 - 10.1097/00004872-200501000-00004
DO - 10.1097/00004872-200501000-00004
M3 - Review article
C2 - 15643116
AN - SCOPUS:19944430327
SN - 0263-6352
VL - 23
SP - 7
EP - 17
JO - Journal of hypertension
JF - Journal of hypertension
IS - 1
ER -