Endothelial dysfunction over the course of coronary artery disease

Enrique Gutiérrez, Andreas J. Flammer, Lilach O. Lerman, Jaime Elízaga, Amir Lerman, Fernández Avilés Francisco

Research output: Contribution to journalReview article

127 Scopus citations

Abstract

The vascular endothelium regulates blood flow in response to physiological needs. Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it constitutes an intermediate step on the progression to adverse events throughout the natural history of coronary artery disease (CAD), often affecting clinical outcomes. Understanding the relation of endothelial function with CAD provides an important pathophysiological insight, which can be useful both in clinical and research management. In this review, wesummarize the current knowledge on endothelial dysfunction and its prognostic influence throughout the natural history ofCAD,from early atherosclerosis to post-transplant management.

Original languageEnglish (US)
Pages (from-to)3175-3182b
JournalEuropean heart journal
Volume34
Issue number41
DOIs
StatePublished - Nov 1 2013

Keywords

  • Acetylcholine
  • Coronary heart disease
  • Endothelial dysfunction
  • Heart failure
  • Heart transplant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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