TY - JOUR
T1 - Endosome-to-TGN Trafficking
T2 - Organelle-Vesicle and Organelle-Organelle Interactions
AU - Tu, Yingfeng
AU - Zhao, Lin
AU - Billadeau, Daniel D.
AU - Jia, Da
N1 - Funding Information:
We thank members of our laboratory for helpful discussions, and Mr. Chengxin Weng for help with making figures. Funding. This research was supported by the National Natural Science Foundation of China (NSFC) grants (#91854121, #31871429, and #81901281), National Key Research and Development Program of China (2018YFC1005004), Sichuan Science and Technology Program (2018RZ0128), and US NIH grant (DK107733 to DB).
PY - 2020/3/18
Y1 - 2020/3/18
N2 - Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular trafficking as well as critical roles of ER-endosome contacts for endosomal trafficking. In this review, we summarize up-to-date knowledge about this trafficking pathway, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts.
AB - Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular trafficking as well as critical roles of ER-endosome contacts for endosomal trafficking. In this review, we summarize up-to-date knowledge about this trafficking pathway, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts.
KW - TBC1D23
KW - TGN
KW - WASH complex
KW - endosome
KW - golgin
KW - human disease
KW - membrane contact site
KW - membrane trafficking
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U2 - 10.3389/fcell.2020.00163
DO - 10.3389/fcell.2020.00163
M3 - Review article
AN - SCOPUS:85082659815
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 163
ER -