Endoscopy-assisted radiofrequency ablation around the coronary sinus ostium in dogs: Its effects on atrioventricular nodal properties and ventricular response during atrial fibrillation

Kazushi Tanaka, Yong-Mei Cha, Osamu Fujimura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Radiofrequency ablation of the slow pathway can prolong atrioventricular (AV) nodal properties and RR intervals during atrial fibrillation (AF) in many patients with AV nodal reentrant tachycardia. However, it is not well elucidated whether these changes are related to the presence of dual AV nodal pathway physiology. The aim of this study was to evaluate changes of AV nodal properties and RR intervals during AF caused by ablation of two specific areas in dogs. Methods and Results: Assisted by fiberoptic endoscopy, linear lesions were created between the coronary sinus ostium and tricuspid valve annulus (area 1) or posterior to the ostium (area 2) in 15 dogs. Three additional dogs served as controls. The measurements were made under autonomic blockade. Catheter ablation could be assisted in all dogs by means of endoscopy. Linear lesions were confirmed at autopsy. AV nodal parameters and RR intervals showed no overall changes. Individual data showed that ablation of area 1 resulted in modification of AV nodal properties in 54.5% (facilitation in 36.3% and inhibition in 18.2%), whereas ablation of area 2 induced changes in 50% (facilitation in 10% and inhibition in 40%). The RR intervals were shortened in 33.3% and 20% and prolonged in 44.5% and 40% after ablation of areas 1 and 2, respectively. The RR intervals during AF correlated well with the Wenckebach cycle length and the AV node functional refractory period before and after ablation (r = 0.78 to 0.94, P < 0.01 for each). Conclusions: Ablation of the two specific areas around the coronary sinus ostium was equally effective in modifying AV nodal properties and the ventricular response during AF without dual AV nodal pathway physiology. The ventricular rate to AF after ablation correlated well with the residual AV nodal properties.

Original languageEnglish (US)
Pages (from-to)1063-1073
Number of pages11
JournalJournal of Cardiovascular Electrophysiology
Volume7
Issue number11
StatePublished - 1996
Externally publishedYes

Fingerprint

Coronary Sinus
Atrial Fibrillation
Endoscopy
Dogs
Atrioventricular Nodal Reentry Tachycardia
Atrioventricular Node
Tricuspid Valve
Catheter Ablation
Autopsy

Keywords

  • angioscopy
  • atrioventricular node
  • autonomic drugs
  • denervation
  • fibrillation
  • modification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

@article{d5bba6ea18fc4ddebde536e18c85f931,
title = "Endoscopy-assisted radiofrequency ablation around the coronary sinus ostium in dogs: Its effects on atrioventricular nodal properties and ventricular response during atrial fibrillation",
abstract = "Introduction: Radiofrequency ablation of the slow pathway can prolong atrioventricular (AV) nodal properties and RR intervals during atrial fibrillation (AF) in many patients with AV nodal reentrant tachycardia. However, it is not well elucidated whether these changes are related to the presence of dual AV nodal pathway physiology. The aim of this study was to evaluate changes of AV nodal properties and RR intervals during AF caused by ablation of two specific areas in dogs. Methods and Results: Assisted by fiberoptic endoscopy, linear lesions were created between the coronary sinus ostium and tricuspid valve annulus (area 1) or posterior to the ostium (area 2) in 15 dogs. Three additional dogs served as controls. The measurements were made under autonomic blockade. Catheter ablation could be assisted in all dogs by means of endoscopy. Linear lesions were confirmed at autopsy. AV nodal parameters and RR intervals showed no overall changes. Individual data showed that ablation of area 1 resulted in modification of AV nodal properties in 54.5{\%} (facilitation in 36.3{\%} and inhibition in 18.2{\%}), whereas ablation of area 2 induced changes in 50{\%} (facilitation in 10{\%} and inhibition in 40{\%}). The RR intervals were shortened in 33.3{\%} and 20{\%} and prolonged in 44.5{\%} and 40{\%} after ablation of areas 1 and 2, respectively. The RR intervals during AF correlated well with the Wenckebach cycle length and the AV node functional refractory period before and after ablation (r = 0.78 to 0.94, P < 0.01 for each). Conclusions: Ablation of the two specific areas around the coronary sinus ostium was equally effective in modifying AV nodal properties and the ventricular response during AF without dual AV nodal pathway physiology. The ventricular rate to AF after ablation correlated well with the residual AV nodal properties.",
keywords = "angioscopy, atrioventricular node, autonomic drugs, denervation, fibrillation, modification",
author = "Kazushi Tanaka and Yong-Mei Cha and Osamu Fujimura",
year = "1996",
language = "English (US)",
volume = "7",
pages = "1063--1073",
journal = "Journal of Cardiovascular Electrophysiology",
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T1 - Endoscopy-assisted radiofrequency ablation around the coronary sinus ostium in dogs

T2 - Its effects on atrioventricular nodal properties and ventricular response during atrial fibrillation

AU - Tanaka, Kazushi

AU - Cha, Yong-Mei

AU - Fujimura, Osamu

PY - 1996

Y1 - 1996

N2 - Introduction: Radiofrequency ablation of the slow pathway can prolong atrioventricular (AV) nodal properties and RR intervals during atrial fibrillation (AF) in many patients with AV nodal reentrant tachycardia. However, it is not well elucidated whether these changes are related to the presence of dual AV nodal pathway physiology. The aim of this study was to evaluate changes of AV nodal properties and RR intervals during AF caused by ablation of two specific areas in dogs. Methods and Results: Assisted by fiberoptic endoscopy, linear lesions were created between the coronary sinus ostium and tricuspid valve annulus (area 1) or posterior to the ostium (area 2) in 15 dogs. Three additional dogs served as controls. The measurements were made under autonomic blockade. Catheter ablation could be assisted in all dogs by means of endoscopy. Linear lesions were confirmed at autopsy. AV nodal parameters and RR intervals showed no overall changes. Individual data showed that ablation of area 1 resulted in modification of AV nodal properties in 54.5% (facilitation in 36.3% and inhibition in 18.2%), whereas ablation of area 2 induced changes in 50% (facilitation in 10% and inhibition in 40%). The RR intervals were shortened in 33.3% and 20% and prolonged in 44.5% and 40% after ablation of areas 1 and 2, respectively. The RR intervals during AF correlated well with the Wenckebach cycle length and the AV node functional refractory period before and after ablation (r = 0.78 to 0.94, P < 0.01 for each). Conclusions: Ablation of the two specific areas around the coronary sinus ostium was equally effective in modifying AV nodal properties and the ventricular response during AF without dual AV nodal pathway physiology. The ventricular rate to AF after ablation correlated well with the residual AV nodal properties.

AB - Introduction: Radiofrequency ablation of the slow pathway can prolong atrioventricular (AV) nodal properties and RR intervals during atrial fibrillation (AF) in many patients with AV nodal reentrant tachycardia. However, it is not well elucidated whether these changes are related to the presence of dual AV nodal pathway physiology. The aim of this study was to evaluate changes of AV nodal properties and RR intervals during AF caused by ablation of two specific areas in dogs. Methods and Results: Assisted by fiberoptic endoscopy, linear lesions were created between the coronary sinus ostium and tricuspid valve annulus (area 1) or posterior to the ostium (area 2) in 15 dogs. Three additional dogs served as controls. The measurements were made under autonomic blockade. Catheter ablation could be assisted in all dogs by means of endoscopy. Linear lesions were confirmed at autopsy. AV nodal parameters and RR intervals showed no overall changes. Individual data showed that ablation of area 1 resulted in modification of AV nodal properties in 54.5% (facilitation in 36.3% and inhibition in 18.2%), whereas ablation of area 2 induced changes in 50% (facilitation in 10% and inhibition in 40%). The RR intervals were shortened in 33.3% and 20% and prolonged in 44.5% and 40% after ablation of areas 1 and 2, respectively. The RR intervals during AF correlated well with the Wenckebach cycle length and the AV node functional refractory period before and after ablation (r = 0.78 to 0.94, P < 0.01 for each). Conclusions: Ablation of the two specific areas around the coronary sinus ostium was equally effective in modifying AV nodal properties and the ventricular response during AF without dual AV nodal pathway physiology. The ventricular rate to AF after ablation correlated well with the residual AV nodal properties.

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KW - atrioventricular node

KW - autonomic drugs

KW - denervation

KW - fibrillation

KW - modification

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