Endoscopic Ultrasound-Guided Celiac Neurolysis

Michael J. Levy, Suresh T. Chari, Maurits J. Wiersema

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Intractable abdominal pain commonly develops in patients with pancreatic cancer. Oral pharmacologic therapy is ineffective for many patients and side effects commonly occur. Celiac neurolysis (CN) is sometimes performed to enhance pain relief. Percutaneous approaches were initially described, with endoscopic ultrasound (EUS)-guided CN more recently introduced. There is uncertainty regarding the efficacy and role of CN in managing pancreatic cancer pain, but CN should still be considered in this difficult-to-treat cohort of patients. EUS-guided approaches may be favored when EUS is otherwise indicated for diagnostic or staging purposes. When EUS is not otherwise indicated, percutaneous approaches are likely favored.

Original languageEnglish (US)
Pages (from-to)231-247
Number of pages17
JournalGastrointestinal Endoscopy Clinics of North America
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • Celiac
  • Ganglia
  • Neurolysis
  • Pain
  • Pancreatic cancer
  • Plexus
  • Splanchnic

ASJC Scopus subject areas

  • Gastroenterology

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