Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus

A multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system

W. L. Curvers, R. Singh, L. M Wong Kee Song, H. C. Wolfsen, K. Ragunath, Kenneth Ke Ning Wang, M. B. Wallace, P. Fockens, J. J G H M Bergman

Research output: Contribution to journalArticle

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Abstract

Objective: To iovestigate the diagnostic potential of endoscopic tri-modal imaging and the relative contribution of each imaging modality (i.e. high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)) for the detection of early neoplasia in Barrett's oesophagus. Design: Prospective multi-centre study. Setting: Tertiary referral centres. Patients: 84 Patients with Barrett's oesophagus. Interventions: The Barrett's oesophagus was inspected with HRE followed by AFI. All lesions detected with HRE and/or AFI were subsequently inspected in detail by NBI for the presence of abnormal mucosal and/or microvascular patterns. Biopsies were obtained from all suspicious lesions for blinded histopathological assessment followed by random biopsies. Main outcome measures: (1) Number of patients with early neoplasia diagnosed by HRE and AFI; (2) number of lesions with early neoplasia detected with HRE and AFI; and (3) reduction of false positive AFI findings after NBI. Results: Per patient analysis; AFI identified all 16 patients with early neoplasia identified with HRE and detected an additional 11 patients with early neoplasia that were not identified with HRE. In three patients no abnormalities were seen but random biopsies revealed HGIN. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (false positive rate of AFI after HRE: 81%). Detailed inspection with NBI reduced this false positive rate to 26%. Conclusions: In this international multi-centre study, the addition of AFI to HRE increased the detection of both the number of patients and the number of lesions with early neoplasia in patients with Barrett's oesophagus. The false positive rate of AFI was reduced after detailed inspection with NBI.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalGut
Volume57
Issue number2
DOIs
StatePublished - Feb 2008

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Narrow Band Imaging
Barrett Esophagus
Optical Imaging
Feasibility Studies
Endoscopy
Neoplasms
Biopsy
Tertiary Care Centers

ASJC Scopus subject areas

  • Gastroenterology

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Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus : A multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. / Curvers, W. L.; Singh, R.; Song, L. M Wong Kee; Wolfsen, H. C.; Ragunath, K.; Wang, Kenneth Ke Ning; Wallace, M. B.; Fockens, P.; Bergman, J. J G H M.

In: Gut, Vol. 57, No. 2, 02.2008, p. 167-172.

Research output: Contribution to journalArticle

Curvers, W. L. ; Singh, R. ; Song, L. M Wong Kee ; Wolfsen, H. C. ; Ragunath, K. ; Wang, Kenneth Ke Ning ; Wallace, M. B. ; Fockens, P. ; Bergman, J. J G H M. / Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus : A multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. In: Gut. 2008 ; Vol. 57, No. 2. pp. 167-172.
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abstract = "Objective: To iovestigate the diagnostic potential of endoscopic tri-modal imaging and the relative contribution of each imaging modality (i.e. high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)) for the detection of early neoplasia in Barrett's oesophagus. Design: Prospective multi-centre study. Setting: Tertiary referral centres. Patients: 84 Patients with Barrett's oesophagus. Interventions: The Barrett's oesophagus was inspected with HRE followed by AFI. All lesions detected with HRE and/or AFI were subsequently inspected in detail by NBI for the presence of abnormal mucosal and/or microvascular patterns. Biopsies were obtained from all suspicious lesions for blinded histopathological assessment followed by random biopsies. Main outcome measures: (1) Number of patients with early neoplasia diagnosed by HRE and AFI; (2) number of lesions with early neoplasia detected with HRE and AFI; and (3) reduction of false positive AFI findings after NBI. Results: Per patient analysis; AFI identified all 16 patients with early neoplasia identified with HRE and detected an additional 11 patients with early neoplasia that were not identified with HRE. In three patients no abnormalities were seen but random biopsies revealed HGIN. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (false positive rate of AFI after HRE: 81{\%}). Detailed inspection with NBI reduced this false positive rate to 26{\%}. Conclusions: In this international multi-centre study, the addition of AFI to HRE increased the detection of both the number of patients and the number of lesions with early neoplasia in patients with Barrett's oesophagus. The false positive rate of AFI was reduced after detailed inspection with NBI.",
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AU - Curvers, W. L.

AU - Singh, R.

AU - Song, L. M Wong Kee

AU - Wolfsen, H. C.

AU - Ragunath, K.

AU - Wang, Kenneth Ke Ning

AU - Wallace, M. B.

AU - Fockens, P.

AU - Bergman, J. J G H M

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