Endoscopic therapy for Barrett's oesophagus

Christopher H. Blevins, Prasad G. Iyer

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Barrett's oesophagus (BO) is thought to progress through the development of dysplasia (low grade and high grade) to oesophageal adenocarcinoma, a lethal cancer with poor survival. The overall goal of endoscopic therapy of BO is to eliminate metaplastic and dysplastic epithelium, to prevent and/or reduce the risk of progression to OAC. Endoscopic therapy techniques can be divided into two broad complementary techniques: tissue acquiring (endoscopic mucosal resection and endoscopic submucosal dissection) and ablative. Endoscopic therapy has been established as safe and effective for the subjects with intra-mucosal cancer (IMC), high-grade dysplasia (HGD) and more recently in treating low-grade dysplasia (LGD). Challenges to endoscopic therapy are being recognized, such as incomplete response and recurrence. While eradication of intestinal metaplasia is the immediate goal of endoscopic therapy, surveillance must continue after complete elimination of intestinal metaplasia, to detect and treat recurrences.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalBest Practice and Research: Clinical Gastroenterology
Volume29
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Barrett's Oesophagus
  • Cryotherapy
  • Endoscopic mucosal resection
  • Endoscopic submucosal dissection
  • Endotherapy
  • Oesophageal adenocarcinoma
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Gastroenterology

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