TY - JOUR
T1 - Endoscopic Therapy for Barrett's Esophagus and Early Esophageal Adenocarcinoma
AU - Leggett, Cadman L.
AU - Gorospe, Emmanuel C.
AU - Wang, Kenneth K.
N1 - Funding Information:
Funding: The authors are supported by NIH U54 CA163004 and CA163004 .
PY - 2013/3
Y1 - 2013/3
N2 - Endoscopic therapy for Barrett's esophagus is feasible and likely to decrease the future risk of development of esophageal adenocarcinoma. The most commonly used therapy is radiofrequency ablation, which has been shown to produce reproducible superficial injury in the esophagus. Other thermal therapies include multipolar coagulation, argon plasma coagulation, and thermal laser therapy. The other end of the ablative spectrum includes cryotherapy, which involves freezing tissue to produce mucosal necrosis. Photodynamic therapy has been used to photochemically eliminate abnormal mucosa. Endoscopic therapy has been demonstrated to be effective in high-risk situations such as Barrett's esophagus with high-grade dysplasia.
AB - Endoscopic therapy for Barrett's esophagus is feasible and likely to decrease the future risk of development of esophageal adenocarcinoma. The most commonly used therapy is radiofrequency ablation, which has been shown to produce reproducible superficial injury in the esophagus. Other thermal therapies include multipolar coagulation, argon plasma coagulation, and thermal laser therapy. The other end of the ablative spectrum includes cryotherapy, which involves freezing tissue to produce mucosal necrosis. Photodynamic therapy has been used to photochemically eliminate abnormal mucosa. Endoscopic therapy has been demonstrated to be effective in high-risk situations such as Barrett's esophagus with high-grade dysplasia.
KW - Argon plasma coagulation
KW - Barrett's esophagus
KW - Cryoablation
KW - Endoscopic mucosal resection
KW - Multipolar electrocoagulation
KW - Photodynamic therapy
KW - Radiofrequency ablation
UR - http://www.scopus.com/inward/record.url?scp=84875294495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875294495&partnerID=8YFLogxK
U2 - 10.1016/j.gtc.2012.11.010
DO - 10.1016/j.gtc.2012.11.010
M3 - Review article
C2 - 23452637
AN - SCOPUS:84875294495
SN - 0889-8553
VL - 42
SP - 175
EP - 185
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 1
ER -