Endoscopic Screening for Barrett's Esophagus and Esophageal Adenocarcinoma: Rationale, Candidates, and Challenges

Research output: Contribution to journalReview articlepeer-review

Abstract

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), a cancer with increasing incidence and poor survival. Risk of EAC in patients with BE is higher compared with the general population. Endoscopic screening for BE is performed to identify patients earlier in the metaplasia-dysplasia-carcinoma sequence from BE to EAC to enable eradication therapy. BE screening should be considered in individuals with multiple risk factors for BE and EAC. Challenges to BE screening include the absence of a cost-effective, widely applicable minimally invasive screening tool, gastroesophageal reflux disease centric screening recommendations, and limitations of current endoscopic surveillance practice.

Original languageEnglish (US)
Pages (from-to)27-41
Number of pages15
JournalGastrointestinal Endoscopy Clinics of North America
Volume31
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Gastroesophageal reflux disease
  • Screening
  • Surveillance

ASJC Scopus subject areas

  • Gastroenterology

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