Endoscopic gastric vagotomy: A feasibility study using laser in dogs

C. M. Radford, D. A. Ahlquist, M. G. Sarr, L. E. Wold, A. R. Zinsmeister, C. J. Gostout

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to explore the feasibility of an endoscopic approach to gastric vagotomy using the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in dogs. Based on gross and histologic measurements, target zones for endoscopic vagotomy were defined with reference to mucosal side landmarks. Target zones containing the unbranched segments of the major intramural vagal branches were linear and symmetrically located anterior and posterior to the midline of the lesser curvature extending from the level of the esophagogastric junction to the proximal antral border. Because of minimal variability between dogs, this zone could be accessed endoscopically and reliably injured. Unfortunately, it was necessary to produce a nearly full thickness burn to interrrupt the deep intramural vagal branches. Despite efforts to control dosimetry, delayed perforations occurred in three of four dogs. We conclude that endoscopic gastric vagotomy using the Nd:YAG laser is not feasible in the dog model because of difficulty controlling the depth of thermal injury. An endoscopic approach to vagotomy remains conceptually appealing because of the predictable location of and accessibility to a target zone.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalGastrointestinal Endoscopy
Volume35
Issue number5
StatePublished - 1989

Fingerprint

Vagotomy
Feasibility Studies
Stomach
Lasers
Dogs
Neodymium
Solid-State Lasers
Esophagogastric Junction
Hot Temperature
Wounds and Injuries

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Radford, C. M., Ahlquist, D. A., Sarr, M. G., Wold, L. E., Zinsmeister, A. R., & Gostout, C. J. (1989). Endoscopic gastric vagotomy: A feasibility study using laser in dogs. Gastrointestinal Endoscopy, 35(5), 419-424.

Endoscopic gastric vagotomy : A feasibility study using laser in dogs. / Radford, C. M.; Ahlquist, D. A.; Sarr, M. G.; Wold, L. E.; Zinsmeister, A. R.; Gostout, C. J.

In: Gastrointestinal Endoscopy, Vol. 35, No. 5, 1989, p. 419-424.

Research output: Contribution to journalArticle

Radford, CM, Ahlquist, DA, Sarr, MG, Wold, LE, Zinsmeister, AR & Gostout, CJ 1989, 'Endoscopic gastric vagotomy: A feasibility study using laser in dogs', Gastrointestinal Endoscopy, vol. 35, no. 5, pp. 419-424.
Radford CM, Ahlquist DA, Sarr MG, Wold LE, Zinsmeister AR, Gostout CJ. Endoscopic gastric vagotomy: A feasibility study using laser in dogs. Gastrointestinal Endoscopy. 1989;35(5):419-424.
Radford, C. M. ; Ahlquist, D. A. ; Sarr, M. G. ; Wold, L. E. ; Zinsmeister, A. R. ; Gostout, C. J. / Endoscopic gastric vagotomy : A feasibility study using laser in dogs. In: Gastrointestinal Endoscopy. 1989 ; Vol. 35, No. 5. pp. 419-424.
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