Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors

Kazuki Sumiyama, Christopher J. Gostout, Elizabeth Rajan, Timothy A. Bakken, Jodie L. Deters, Mary A. Knipschield

Research output: Contribution to journalArticle

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Abstract

Background: A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model. Objectives: Six pigs. Design: Short-term survival animal study. Settings: Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall. Interventions: Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation. Main Outcome Measurements: One week follow-up endoscopy and necropsy were performed. Results: Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations. Conclusions: Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalGastrointestinal Endoscopy
Volume65
Issue number1
DOIs
StatePublished - Jan 2007

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Stomach
Swine
Equipment and Supplies
Endoscopy
General Anesthesia
Sutures
Needles
Catheters

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sumiyama, K., Gostout, C. J., Rajan, E., Bakken, T. A., Deters, J. L., & Knipschield, M. A. (2007). Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors. Gastrointestinal Endoscopy, 65(1), 134-139. https://doi.org/10.1016/j.gie.2006.01.050

Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors. / Sumiyama, Kazuki; Gostout, Christopher J.; Rajan, Elizabeth; Bakken, Timothy A.; Deters, Jodie L.; Knipschield, Mary A.

In: Gastrointestinal Endoscopy, Vol. 65, No. 1, 01.2007, p. 134-139.

Research output: Contribution to journalArticle

Sumiyama, K, Gostout, CJ, Rajan, E, Bakken, TA, Deters, JL & Knipschield, MA 2007, 'Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors', Gastrointestinal Endoscopy, vol. 65, no. 1, pp. 134-139. https://doi.org/10.1016/j.gie.2006.01.050
Sumiyama, Kazuki ; Gostout, Christopher J. ; Rajan, Elizabeth ; Bakken, Timothy A. ; Deters, Jodie L. ; Knipschield, Mary A. / Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors. In: Gastrointestinal Endoscopy. 2007 ; Vol. 65, No. 1. pp. 134-139.
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