Endoscopic and histologic diagnosis of Barrett esophagus

E. Rajan, L. J. Burgart, C. J. Gostout

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Endoscopy plays an important role in the identification, diagnosis, and treatment of Barrett esophagus. Short-segment (<2-3 cm) and traditional long-segment (>2-3 cm) Barrett esophagus are distinguished solely on the length of metaplastic tissue above the esophagogastric junction. The histologic hallmark of intestinal metaplasia is required to confirm diagnosis. Biopsy specimens obtained from tissue of presumed Barrett esophagus or an irregular Z line confirm metaplastic glandular mucosa and permit evaluation of dysplastic or neoplastic changes. In the appropriate clinical setting, the use of adjunctive diagnostic techniques may facilitate the diagnosis of Barrett esophagus and sequelae such as dysplasia. Chromoendoscopy with high-resolution or magnified endoscopy is simple, safe, and desirable for surveillance but requires additional procedural time. The use of light-induced fluorescence endoscopy and light-scattering spectroscopy(ie, optical biopsy) is appealing for the diagnosis and characterization of suspicious lesions. Adjunctive endoscopic techniques and adherence to a protocol for performing biopsies facilitate the early detection and subsequent surveillance of Barrett esophagus.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalMayo Clinic Proceedings
Volume76
Issue number2
StatePublished - 2001

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Barrett Esophagus
Endoscopy
Biopsy
Light
Esophagogastric Junction
Metaplasia
Spectrum Analysis
Mucous Membrane
Fluorescence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rajan, E., Burgart, L. J., & Gostout, C. J. (2001). Endoscopic and histologic diagnosis of Barrett esophagus. Mayo Clinic Proceedings, 76(2), 217-225.

Endoscopic and histologic diagnosis of Barrett esophagus. / Rajan, E.; Burgart, L. J.; Gostout, C. J.

In: Mayo Clinic Proceedings, Vol. 76, No. 2, 2001, p. 217-225.

Research output: Contribution to journalArticle

Rajan, E, Burgart, LJ & Gostout, CJ 2001, 'Endoscopic and histologic diagnosis of Barrett esophagus', Mayo Clinic Proceedings, vol. 76, no. 2, pp. 217-225.
Rajan E, Burgart LJ, Gostout CJ. Endoscopic and histologic diagnosis of Barrett esophagus. Mayo Clinic Proceedings. 2001;76(2):217-225.
Rajan, E. ; Burgart, L. J. ; Gostout, C. J. / Endoscopic and histologic diagnosis of Barrett esophagus. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 2. pp. 217-225.
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