Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic fibrosis, but the role it plays varies depending on the cause and progression of the disease. Furthermore, ER stress plays a distinct role in hepatocytes versus hepatic stellate cells (HSCs), which adds to the complexity of understanding ER stress and its downstream signaling through the unfolded protein response (UPR) in liver disease. Here, the authors focus on the current literature of ER stress in nonalcoholic and alcoholic fatty liver diseases, how ER stress impacts hepatocyte injury, and the role of ER stress in HSC activation and hepatic fibrosis. This review provides insight into the complex signaling and regulation of the UPR, parallels and distinctions between different liver diseases, and how ER stress may be targeted as an antisteatotic or antifibrotic therapy to limit the progression of liver disease.

Original languageEnglish (US)
Pages (from-to)235-248
Number of pages14
JournalSeminars in Liver Disease
Volume39
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

Endoplasmic Reticulum Stress
Metabolic Diseases
Liver Diseases
Fibrosis
Liver
Unfolded Protein Response
Hepatic Stellate Cells
Hepatocytes
Alcoholic Fatty Liver
Alcoholic Liver Diseases
Disease Progression
Wounds and Injuries

Keywords

  • hepatic stellate cells
  • nonalcoholic fatty liver disease
  • steatosis
  • Unfolded protein response

ASJC Scopus subject areas

  • Hepatology

Cite this

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis. / Maiers, Jessica; Malhi, Harmeet M.

In: Seminars in Liver Disease, Vol. 39, No. 2, 01.01.2019, p. 235-248.

Research output: Contribution to journalArticle

@article{db0e28d59b754cbfafa308e8d13d7858,
title = "Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis",
abstract = "Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic fibrosis, but the role it plays varies depending on the cause and progression of the disease. Furthermore, ER stress plays a distinct role in hepatocytes versus hepatic stellate cells (HSCs), which adds to the complexity of understanding ER stress and its downstream signaling through the unfolded protein response (UPR) in liver disease. Here, the authors focus on the current literature of ER stress in nonalcoholic and alcoholic fatty liver diseases, how ER stress impacts hepatocyte injury, and the role of ER stress in HSC activation and hepatic fibrosis. This review provides insight into the complex signaling and regulation of the UPR, parallels and distinctions between different liver diseases, and how ER stress may be targeted as an antisteatotic or antifibrotic therapy to limit the progression of liver disease.",
keywords = "hepatic stellate cells, nonalcoholic fatty liver disease, steatosis, Unfolded protein response",
author = "Jessica Maiers and Malhi, {Harmeet M}",
year = "2019",
month = "1",
day = "1",
doi = "10.1055/s-0039-1681032",
language = "English (US)",
volume = "39",
pages = "235--248",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "2",

}

TY - JOUR

T1 - Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

AU - Maiers, Jessica

AU - Malhi, Harmeet M

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic fibrosis, but the role it plays varies depending on the cause and progression of the disease. Furthermore, ER stress plays a distinct role in hepatocytes versus hepatic stellate cells (HSCs), which adds to the complexity of understanding ER stress and its downstream signaling through the unfolded protein response (UPR) in liver disease. Here, the authors focus on the current literature of ER stress in nonalcoholic and alcoholic fatty liver diseases, how ER stress impacts hepatocyte injury, and the role of ER stress in HSC activation and hepatic fibrosis. This review provides insight into the complex signaling and regulation of the UPR, parallels and distinctions between different liver diseases, and how ER stress may be targeted as an antisteatotic or antifibrotic therapy to limit the progression of liver disease.

AB - Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic fibrosis, but the role it plays varies depending on the cause and progression of the disease. Furthermore, ER stress plays a distinct role in hepatocytes versus hepatic stellate cells (HSCs), which adds to the complexity of understanding ER stress and its downstream signaling through the unfolded protein response (UPR) in liver disease. Here, the authors focus on the current literature of ER stress in nonalcoholic and alcoholic fatty liver diseases, how ER stress impacts hepatocyte injury, and the role of ER stress in HSC activation and hepatic fibrosis. This review provides insight into the complex signaling and regulation of the UPR, parallels and distinctions between different liver diseases, and how ER stress may be targeted as an antisteatotic or antifibrotic therapy to limit the progression of liver disease.

KW - hepatic stellate cells

KW - nonalcoholic fatty liver disease

KW - steatosis

KW - Unfolded protein response

UR - http://www.scopus.com/inward/record.url?scp=85065196771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065196771&partnerID=8YFLogxK

U2 - 10.1055/s-0039-1681032

DO - 10.1055/s-0039-1681032

M3 - Article

C2 - 30912096

AN - SCOPUS:85065196771

VL - 39

SP - 235

EP - 248

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 2

ER -