Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: Electrophysiologic studies on normal and demyelinated rat nerves

Phillip A. Low; James Schmelzer; Peter James Dyck; John J. Kelly

doi:10.1212/wnl.32.7.720

Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: Electrophysiologic studies on normal and demyelinated rat nerves

Phillip A. Low, James Schmelzer, Peter James Dyck, John J. Kelly

Neurology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any elec trophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.

Original language	English (US)
Pages (from-to)	720-724
Number of pages	5
Journal	Neurology
Volume	32
Issue number	7
DOIs	https://doi.org/10.1212/wnl.32.7.720
State	Published - Jul 1982

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any elec trophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.",

author = "Low, {Phillip A.} and James Schmelzer and Dyck, {Peter James} and Kelly, {John J.}",

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AU - Dyck, Peter James

AU - Kelly, John J.

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AB - Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any elec trophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.

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Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: Electrophysiologic studies on normal and demyelinated rat nerves

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