Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: Electrophysiologic studies on normal and demyelinated rat nerves

Phillip A. Low, James Schmelzer, Peter James Dyck, John J. Kelly

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any elec trophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.

Original languageEnglish (US)
Pages (from-to)720-724
Number of pages5
JournalNeurology
Volume32
Issue number7
DOIs
StatePublished - Jul 1982

ASJC Scopus subject areas

  • Clinical Neurology

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