Endogenous superantigens shape response to exogenous superantigens

Govindarajan Rajagopalan; Manisha Singh; Moon M. Sen; Narayana S. Murali; Karl A. Nath; Chella S. David

doi:10.1128/CDLI.12.9.1119-1122.2005

Endogenous superantigens shape response to exogenous superantigens

Govindarajan Rajagopalan, Manisha Singh, Moon M. Sen, Narayana S. Murali, Karl A. Nath, Chella S. David

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 ⁺ T cells, was significantly reduced and conferred protection from superantigen-induced mortality.

Original language	English (US)
Pages (from-to)	1119-1122
Number of pages	4
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1128/CDLI.12.9.1119-1122.2005
State	Published - Sep 2005

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CDLI.12.9.1119-1122.2005

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AU - Singh, Manisha

AU - Sen, Moon M.

AU - Murali, Narayana S.

AU - Nath, Karl A.

AU - David, Chella S.

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AB - Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was significantly reduced and conferred protection from superantigen-induced mortality.

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Endogenous superantigens shape response to exogenous superantigens

Abstract

ASJC Scopus subject areas

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