Endogenous superantigens shape response to exogenous superantigens

Govindarajan Rajagopalan, Manisha Singh, Moon M. Sen, Narayana S. Murali, Karl A Nath, Chella S. David

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was significantly reduced and conferred protection from superantigen-induced mortality.

Original languageEnglish (US)
Pages (from-to)1119-1122
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume12
Issue number9
DOIs
StatePublished - Sep 2005

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Superantigens
T-cells
T-Cell Antigen Receptor
Bearings (structural)
T-Lymphocytes
Mortality

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Clinical Biochemistry
  • Immunology

Cite this

Endogenous superantigens shape response to exogenous superantigens. / Rajagopalan, Govindarajan; Singh, Manisha; Sen, Moon M.; Murali, Narayana S.; Nath, Karl A; David, Chella S.

In: Clinical and Diagnostic Laboratory Immunology, Vol. 12, No. 9, 09.2005, p. 1119-1122.

Research output: Contribution to journalArticle

Rajagopalan, Govindarajan ; Singh, Manisha ; Sen, Moon M. ; Murali, Narayana S. ; Nath, Karl A ; David, Chella S. / Endogenous superantigens shape response to exogenous superantigens. In: Clinical and Diagnostic Laboratory Immunology. 2005 ; Vol. 12, No. 9. pp. 1119-1122.
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