Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization

Johannes D. Veldhuis; Alan D. Rogol; Gregorio Perez-Palacios; Paul Stumpf; James D. Kitchin; Maria L. Dufau

doi:10.1210/jcem-61-4-790

Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization

Johannes D. Veldhuis, Alan D. Rogol, Gregorio Perez-Palacios, Paul Stumpf, James D. Kitchin, Maria L. Dufau

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization. In response to an opiate antagonist, LH pulse frequency increased from 3.0 ± 0.55 (±SE) to 5.0 ± 0.45 pulses/8 h (P = 0.034). Since these patients have inborn target tissue resistance to androgens, we infer that sustained androgen action is not obligatory to the emergence of endogenous inhibitory opiate tone in man. Rather, these observations document that the suppressive effects of opiates on gonadotropin secretion can be unmasked in the presence of an unopposed estrogen milieu.

Original language	English (US)
Pages (from-to)	790-793
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	61
Issue number	4
DOIs	https://doi.org/10.1210/jcem-61-4-790
State	Published - Oct 1985

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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Veldhuis, J. D., Rogol, A. D., Perez-Palacios, G., Stumpf, P., Kitchin, J. D., & Dufau, M. L. (1985). Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization. Journal of Clinical Endocrinology and Metabolism, 61(4), 790-793. https://doi.org/10.1210/jcem-61-4-790

Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu : Studies in estrogen-replaced, gonadectomized patients with testicular feminization. / Veldhuis, Johannes D.; Rogol, Alan D.; Perez-Palacios, Gregorio et al.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 61, No. 4, 10.1985, p. 790-793.

Research output: Contribution to journal › Article › peer-review

Veldhuis, JD, Rogol, AD, Perez-Palacios, G, Stumpf, P, Kitchin, JD & Dufau, ML 1985, 'Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization', Journal of Clinical Endocrinology and Metabolism, vol. 61, no. 4, pp. 790-793. https://doi.org/10.1210/jcem-61-4-790

Veldhuis JD, Rogol AD, Perez-Palacios G, Stumpf P, Kitchin JD, Dufau ML. Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization. Journal of Clinical Endocrinology and Metabolism. 1985 Oct;61(4):790-793. doi: 10.1210/jcem-61-4-790

Veldhuis, Johannes D. ; Rogol, Alan D. ; Perez-Palacios, Gregorio et al. / Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu : Studies in estrogen-replaced, gonadectomized patients with testicular feminization. In: Journal of Clinical Endocrinology and Metabolism. 1985 ; Vol. 61, No. 4. pp. 790-793.

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abstract = "Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization. In response to an opiate antagonist, LH pulse frequency increased from 3.0 ± 0.55 (±SE) to 5.0 ± 0.45 pulses/8 h (P = 0.034). Since these patients have inborn target tissue resistance to androgens, we infer that sustained androgen action is not obligatory to the emergence of endogenous inhibitory opiate tone in man. Rather, these observations document that the suppressive effects of opiates on gonadotropin secretion can be unmasked in the presence of an unopposed estrogen milieu.",

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Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: Studies in estrogen-replaced, gonadectomized patients with testicular feminization

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