Abstract
Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization. In response to an opiate antagonist, LH pulse frequency increased from 3.0 ± 0.55 (± SE) to 5.0 ± 0.45 pulses/8 h (P = 0.034). Since these patients have inborn target tissue resistance to androgens, we infer that sustained androgen action is not obligatory to the emergence of endogenous inhibitory opiate tone in man. Rather, these observations document that the suppressive effects of opiates on gonadotropin secretion can be unmasked in the presence of an unopposed estrogen milieu.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 790-793 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 61 |
| Issue number | 4 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu : Studies in estrogen-replaced, gonadectomized patients with testicular feminization. / Veldhuis, Johannes D; Rogol, A. D.; Perez-Palacios, G.; Stumpf, P.; Kitchin, J. D.; Dufau, M. L.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 61, No. 4, 1985, p. 790-793.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu
T2 - Studies in estrogen-replaced, gonadectomized patients with testicular feminization
AU - Veldhuis, Johannes D
AU - Rogol, A. D.
AU - Perez-Palacios, G.
AU - Stumpf, P.
AU - Kitchin, J. D.
AU - Dufau, M. L.
PY - 1985
Y1 - 1985
N2 - Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization. In response to an opiate antagonist, LH pulse frequency increased from 3.0 ± 0.55 (± SE) to 5.0 ± 0.45 pulses/8 h (P = 0.034). Since these patients have inborn target tissue resistance to androgens, we infer that sustained androgen action is not obligatory to the emergence of endogenous inhibitory opiate tone in man. Rather, these observations document that the suppressive effects of opiates on gonadotropin secretion can be unmasked in the presence of an unopposed estrogen milieu.
AB - Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization. In response to an opiate antagonist, LH pulse frequency increased from 3.0 ± 0.55 (± SE) to 5.0 ± 0.45 pulses/8 h (P = 0.034). Since these patients have inborn target tissue resistance to androgens, we infer that sustained androgen action is not obligatory to the emergence of endogenous inhibitory opiate tone in man. Rather, these observations document that the suppressive effects of opiates on gonadotropin secretion can be unmasked in the presence of an unopposed estrogen milieu.
UR - http://www.scopus.com/inward/record.url?scp=0022413371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022413371&partnerID=8YFLogxK
M3 - Article
C2 - 4031019
AN - SCOPUS:0022413371
VL - 61
SP - 790
EP - 793
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -