Endocytosis of calcium oxalate crystals and proliferation of renal tubular epithelial cells in a patient with type 1 primary hyperoxaluria

J. C. Lieske, B. H. Spargo, F. G. Toback

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

A patient with primary hyperoxaluria who received a liver-kidney transplant is presented. A postoperative renal biopsy showed apparent tubular cell endocytosis of calcium oxalate crystals and cell proliferation, indicating that renal epithelial cells do not perceive urinary crystals as inert. Such cellular responses to crystals may have a role in nephrolithiasis.

Original languageEnglish (US)
Pages (from-to)1517-1519
Number of pages3
JournalJournal of Urology
Volume148
Issue number5 I
DOIs
StatePublished - Jan 1 1992

Keywords

  • calcium oxalate
  • hyperoxaluria
  • kidney transplantation
  • liver transplantation
  • urinary calculi

ASJC Scopus subject areas

  • Urology

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