Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981

I. Epidemiology

Ettore Beghi, Alfredo Nicolosi, Leonard T. Kurland, Donald W. Mulder, W. Allen Hauser, Lynne Shuster

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

All cases fulfilling stated criteria for encephalitis and aspectic meningitis in Olmsted County, Minnesota, for the period 1950 through 1981 were identified. This is, to our knowledge, the first such incidence and trend study in a delineated population, providing rates per 100,000 person‐years of 7.4 for encephalitis (189 cases) and 10.9 for aseptic menigitis (283 cases). These are about twelve and six times higher, respectively, than the rates reported by the Centers for Disease Control. The rates have been stable over successive 5‐ or 10‐year periods except for a recent increase in aseptic meningitis. Both conditions were more common in the summer months, in childhood, and among males. Viral identification using conventional laboratory tests has improved with time; in the period 1970 through 1981, virus type was specified in about one‐fourth of the cases. The most common agents identified were California and mumps viruses in encephalitis, and entero and mumps viruses in aseptic meningitis. Antecedent and/or concurrent infections were noted in 42 and 35% of encephalitis and aseptic meningitis cases, respectively. No case due to mumps, measles, or rubella viruses has occurred since 1972, reflecting the impact of immunizations. Recovery was reported at the end of the acute phase in 95% of patients with aseptic meningitis, and there were no deaths. Seventy‐eight percent of encephalitis patients recovered completely; the case fatality rate was 3.8%. Of the encephalitis cases, 2% were diagnosed initially postmortem.

Original languageEnglish (US)
Pages (from-to)283-294
Number of pages12
JournalAnnals of Neurology
Volume16
Issue number3
DOIs
StatePublished - Jan 1 1984

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Aseptic Meningitis
Encephalitis
Mumps virus
Epidemiology
California Encephalitis Viruses
Encephalitis Viruses
Rubella virus
Measles virus
Centers for Disease Control and Prevention (U.S.)
Meningitis
Immunization
Cohort Studies
Viruses
Mortality
Infection
Population

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Beghi, E., Nicolosi, A., Kurland, L. T., Mulder, D. W., Hauser, W. A., & Shuster, L. (1984). Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981: I. Epidemiology. Annals of Neurology, 16(3), 283-294. https://doi.org/10.1002/ana.410160304

Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981 : I. Epidemiology. / Beghi, Ettore; Nicolosi, Alfredo; Kurland, Leonard T.; Mulder, Donald W.; Hauser, W. Allen; Shuster, Lynne.

In: Annals of Neurology, Vol. 16, No. 3, 01.01.1984, p. 283-294.

Research output: Contribution to journalArticle

Beghi, E, Nicolosi, A, Kurland, LT, Mulder, DW, Hauser, WA & Shuster, L 1984, 'Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981: I. Epidemiology', Annals of Neurology, vol. 16, no. 3, pp. 283-294. https://doi.org/10.1002/ana.410160304
Beghi, Ettore ; Nicolosi, Alfredo ; Kurland, Leonard T. ; Mulder, Donald W. ; Hauser, W. Allen ; Shuster, Lynne. / Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981 : I. Epidemiology. In: Annals of Neurology. 1984 ; Vol. 16, No. 3. pp. 283-294.
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