Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

Peter J. Grahn; Igor A. Lavrov; Dimitry G. Sayenko; Meegan G. Van Straaten; Megan L. Gill; Jeffrey A. Strommen; Jonathan S. Calvert; Dina I. Drubach; Lisa A. Beck; Margaux B. Linde; Andrew R. Thoreson; Cesar Lopez; Aldo A. Mendez; Parag N. Gad; Yury P. Gerasimenko; V. Reggie Edgerton; Kristin D. Zhao; Kendall H. Lee

doi:10.1016/j.mayocp.2017.02.014

Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

Peter J. Grahn, Igor A. Lavrov, Dimitry G. Sayenko, Meegan G. Van Straaten, Megan L. Gill, Jeffrey A. Strommen, Jonathan S. Calvert, Dina I. Drubach, Lisa A. Beck, Margaux B. Linde, Andrew R. Thoreson, Cesar Lopez, Aldo A. Mendez, Parag N. Gad, Yury P. Gerasimenko, V. Reggie Edgerton, Kristin D. Zhao, Kendall H. Lee

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Abstract

We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.

Original language	English (US)
Pages (from-to)	544-554
Number of pages	11
Journal	Mayo Clinic proceedings
Volume	92
Issue number	4
DOIs	https://doi.org/10.1016/j.mayocp.2017.02.014
State	Published - Apr 1 2017

ASJC Scopus subject areas

General Medicine

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10.1016/j.mayocp.2017.02.014

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Grahn, P. J., Lavrov, I. A., Sayenko, D. G., Van Straaten, M. G., Gill, M. L., Strommen, J. A., Calvert, J. S., Drubach, D. I., Beck, L. A., Linde, M. B., Thoreson, A. R., Lopez, C., Mendez, A. A., Gad, P. N., Gerasimenko, Y. P., Edgerton, V. R., Zhao, K. D., & Lee, K. H. (2017). Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia. Mayo Clinic proceedings, 92(4), 544-554. https://doi.org/10.1016/j.mayocp.2017.02.014

Grahn, PJ, Lavrov, IA, Sayenko, DG, Van Straaten, MG, Gill, ML, Strommen, JA, Calvert, JS, Drubach, DI, Beck, LA, Linde, MB, Thoreson, AR, Lopez, C, Mendez, AA, Gad, PN, Gerasimenko, YP, Edgerton, VR, Zhao, KD & Lee, KH 2017, 'Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia', Mayo Clinic proceedings, vol. 92, no. 4, pp. 544-554. https://doi.org/10.1016/j.mayocp.2017.02.014

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abstract = "We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.",

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Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

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