Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

Peter J. Grahn, Igor A. Lavrov, Dimitry G. Sayenko, Meegan G. Van Straaten, Megan L. Gill, Jeffrey A. Strommen, Jonathan S. Calvert, Dina I. Drubach, Lisa A. Beck, Margaux B. Linde, Andrew R. Thoreson, Cesar Lopez, Aldo A. Mendez, Parag N. Gad, Yury P. Gerasimenko, V. Reggie Edgerton, Kristin D Zhao, Kendall H Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.

Original languageEnglish (US)
Pages (from-to)544-554
Number of pages11
JournalMayo Clinic Proceedings
Volume92
Issue number4
DOIs
StatePublished - Apr 1 2017

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Paraplegia
Spinal Cord
Muscles
Electric Stimulation
Electric Stimulation Therapy
Spinal Cord Stimulation
Body Weight

ASJC Scopus subject areas

  • Medicine(all)

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Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia. / Grahn, Peter J.; Lavrov, Igor A.; Sayenko, Dimitry G.; Van Straaten, Meegan G.; Gill, Megan L.; Strommen, Jeffrey A.; Calvert, Jonathan S.; Drubach, Dina I.; Beck, Lisa A.; Linde, Margaux B.; Thoreson, Andrew R.; Lopez, Cesar; Mendez, Aldo A.; Gad, Parag N.; Gerasimenko, Yury P.; Edgerton, V. Reggie; Zhao, Kristin D; Lee, Kendall H.

In: Mayo Clinic Proceedings, Vol. 92, No. 4, 01.04.2017, p. 544-554.

Research output: Contribution to journalArticle

Grahn, PJ, Lavrov, IA, Sayenko, DG, Van Straaten, MG, Gill, ML, Strommen, JA, Calvert, JS, Drubach, DI, Beck, LA, Linde, MB, Thoreson, AR, Lopez, C, Mendez, AA, Gad, PN, Gerasimenko, YP, Edgerton, VR, Zhao, KD & Lee, KH 2017, 'Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia', Mayo Clinic Proceedings, vol. 92, no. 4, pp. 544-554. https://doi.org/10.1016/j.mayocp.2017.02.014
Grahn, Peter J. ; Lavrov, Igor A. ; Sayenko, Dimitry G. ; Van Straaten, Meegan G. ; Gill, Megan L. ; Strommen, Jeffrey A. ; Calvert, Jonathan S. ; Drubach, Dina I. ; Beck, Lisa A. ; Linde, Margaux B. ; Thoreson, Andrew R. ; Lopez, Cesar ; Mendez, Aldo A. ; Gad, Parag N. ; Gerasimenko, Yury P. ; Edgerton, V. Reggie ; Zhao, Kristin D ; Lee, Kendall H. / Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia. In: Mayo Clinic Proceedings. 2017 ; Vol. 92, No. 4. pp. 544-554.
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