Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD

Jack Stevens; Kelly Kelleher; Joel Greenhouse; Guanmin Chen; Huiyun Xiang; Eloise Kaizar; Peter S. Jensen; L. Eugene Arnold

doi:10.1007/s10488-006-0097-4

Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD

Jack Stevens, Kelly Kelleher, Joel Greenhouse, Guanmin Chen, Huiyun Xiang, Eloise Kaizar, Peter S. Jensen, L. Eugene Arnold

Psychiatry and Psychology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Randomized controlled trials (RCTs) are criticized for the questionable generalizability of their patient samples to real world populations. This study compared the demographic and clinical characteristics of children from the Multimodal Treatment Study of Children with ADHD (MTA) to those from the NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study and the National Health and Nutrition Examination Survey (NHANES). On the whole, we found no compelling evidence against the representativeness of the MTA sample, but the limited power from MECA and NHANES may have lead to noteworthy differences between datasets being statistically nonsignificant.

Original language	English (US)
Pages (from-to)	221-232
Number of pages	12
Journal	Administration and Policy in Mental Health and Mental Health Services Research
Volume	34
Issue number	3
DOIs	https://doi.org/10.1007/s10488-006-0097-4
State	Published - May 2007

Keywords

ADHD
External validity
Generalizability

ASJC Scopus subject areas

Phychiatric Mental Health
Health Policy
Public Health, Environmental and Occupational Health
Psychiatry and Mental health

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10.1007/s10488-006-0097-4

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title = "Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD",

abstract = "Randomized controlled trials (RCTs) are criticized for the questionable generalizability of their patient samples to real world populations. This study compared the demographic and clinical characteristics of children from the Multimodal Treatment Study of Children with ADHD (MTA) to those from the NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study and the National Health and Nutrition Examination Survey (NHANES). On the whole, we found no compelling evidence against the representativeness of the MTA sample, but the limited power from MECA and NHANES may have lead to noteworthy differences between datasets being statistically nonsignificant.",

keywords = "ADHD, External validity, Generalizability",

author = "Jack Stevens and Kelly Kelleher and Joel Greenhouse and Guanmin Chen and Huiyun Xiang and Eloise Kaizar and Jensen, {Peter S.} and Arnold, {L. Eugene}",

note = "Funding Information: This study was supported in part by NIMH grants MH66960, MH65430, and MH30915. The Multimodal Treatment Study of Children with Attention Deficit/Hyperactivity Disorder (MTA) was conducted and supported by the National Institute of Mental Health (NIMH) in collaboration with the MTA Investigators. The NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study was conducted and supported by the National Institute of Mental Health (NIMH) in collaboration with the MECA investigators. This manuscript reflects the views of the authors and may not reflect the opinions or views of all the MTA investigators, the MECA investigators, or NIMH.",

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AU - Chen, Guanmin

AU - Xiang, Huiyun

AU - Kaizar, Eloise

AU - Jensen, Peter S.

AU - Arnold, L. Eugene

N1 - Funding Information: This study was supported in part by NIMH grants MH66960, MH65430, and MH30915. The Multimodal Treatment Study of Children with Attention Deficit/Hyperactivity Disorder (MTA) was conducted and supported by the National Institute of Mental Health (NIMH) in collaboration with the MTA Investigators. The NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study was conducted and supported by the National Institute of Mental Health (NIMH) in collaboration with the MECA investigators. This manuscript reflects the views of the authors and may not reflect the opinions or views of all the MTA investigators, the MECA investigators, or NIMH.

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AB - Randomized controlled trials (RCTs) are criticized for the questionable generalizability of their patient samples to real world populations. This study compared the demographic and clinical characteristics of children from the Multimodal Treatment Study of Children with ADHD (MTA) to those from the NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study and the National Health and Nutrition Examination Survey (NHANES). On the whole, we found no compelling evidence against the representativeness of the MTA sample, but the limited power from MECA and NHANES may have lead to noteworthy differences between datasets being statistically nonsignificant.

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KW - External validity

KW - Generalizability

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Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD

Abstract

Keywords

ASJC Scopus subject areas

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