Emerging Treatments in Episodic Migraine

Kate W. Grimsrud, Rashmi B Halker Singh

Research output: Contribution to journalReview article

9 Scopus citations


Purpose of Review: The purpose of this review is to evaluate and describe recent and emerging treatment options for episodic migraine. Recent Findings: Recent advances have been made in better understanding the pathophysiology of migraine, which has led to further investigation of potential new pharmacologic and non-pharmacologic treatment options. Summary: A number of new medications are emerging for the acute and preventive treatment of migraine, including CGRP monoclonal antibodies, CGRP receptor antagonists, serotonin 5-HT1F agonists, and PACAP receptor monoclonal antibodies. Additionally, newer studies on existing non-invasive neuromodulation devices including transcranial magnetic stimulation, supraorbital transcutaneous nerve stimulation, and transcutaneous vagus nerve stimulation have recently received FDA approval for use in migraine. Neuromodulation devices including percutaneous mastoid electrical stimulation, non-painful remote electrical stimulation, and caloric vestibular stimulation are undergoing further investigation and have shown promising results thus far. These new developments are expected to contribute to better treatment and decreased disability in migraine.

Original languageEnglish (US)
Article number61
JournalCurrent Pain and Headache Reports
Issue number9
StatePublished - Sep 1 2018


  • Calcitonin gene-related peptide
  • Episodic migraine
  • Neuromodulation
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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