Emerging therapeutic options for Waldenström macroglobulinemia/lymphoplasmacytic lymphoma

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5 Scopus citations

Abstract

Lymphoplasmacytic lymphoma is an indolent B-cell, non-Hodgkin lymphoma (NHL), the majority of which are characterized by production of a monoclonal immunoglobulin M (IgM) protein and are known as Waldenström macroglobulinemia. Identification of highly recurrent activating somatic mutation in MYD88 has improved our understanding of the pathogenesis of Waldenström macroglobulinemia and has therapeutic implications. Here, we review novel therapeutic agents in Waldenström macroglobulinemia/lymphoplasmacytic lymphoma, which have emerged in the past decade and discuss their comparative efficacy and safety, with emphasis on a Brutons tyrosine kinase (BTK) inhibitor, which has been recently approved by the US FDA, specifically for Waldenström macroglobulinemia/lymphoplasmacytic lymphoma. Future research should focus on identifying targeted agents against activating mutations and long-term data for currently available novel agents should be critically evaluated, both in treatment-naïve and in relapsed/refractory settings.

Original languageEnglish (US)
Pages (from-to)1143-1156
Number of pages14
JournalExpert Review of Anticancer Therapy
Volume15
Issue number10
DOIs
StatePublished - Oct 3 2015

Keywords

  • bendamustine
  • BTK inhibitors
  • HDAC inhibitors
  • immunomodulators
  • mTOR inhibitors
  • MYD88L265P
  • PI3K/AKT/PKC inhibitors
  • proteasome inhibitors
  • Waldenström macroglobulinemia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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