TY - JOUR
T1 - Emerging therapeutic opportunities for skeletal restoration
AU - Kawai, Masanobu
AU - Mödder, Ulrike I.
AU - Khosla, Sundeep
AU - Rosen, Clifford J.
N1 - Funding Information:
this work is supported by United States national Institutes of Health grants AR45433-13, AG004875, AG028936 and AR027965.
PY - 2011/2
Y1 - 2011/2
N2 - Osteoporosis, a syndrome characterized by thin bones and fractures, has become more prevalent in both women and men. Established therapies for treating this disorder consist primarily of drugs that prevent bone loss, such as the bisphosphonates and selective oestrogen receptor modulators. Although these drugs have been shown to reduce fractures in randomized trials, there is an urgent need for treatments that could lower fracture risk further without additional adverse effects. The introduction of parathyroid hormone (teriparatide), which significantly increases bone mineral density, albeit for a relatively short duration, raised expectations that drugs that stimulate bone formation might cure osteoporosis. After outlining current approaches for treating osteoporosis, this Review focuses on emerging therapeutic opportunities for osteoporosis that are based on recent insights into skeletal physiology. Such novel strategies offer promise not only for reducing age-related bone loss and the associated risk of fractures but also for restoring bone mineral density to healthy levels.
AB - Osteoporosis, a syndrome characterized by thin bones and fractures, has become more prevalent in both women and men. Established therapies for treating this disorder consist primarily of drugs that prevent bone loss, such as the bisphosphonates and selective oestrogen receptor modulators. Although these drugs have been shown to reduce fractures in randomized trials, there is an urgent need for treatments that could lower fracture risk further without additional adverse effects. The introduction of parathyroid hormone (teriparatide), which significantly increases bone mineral density, albeit for a relatively short duration, raised expectations that drugs that stimulate bone formation might cure osteoporosis. After outlining current approaches for treating osteoporosis, this Review focuses on emerging therapeutic opportunities for osteoporosis that are based on recent insights into skeletal physiology. Such novel strategies offer promise not only for reducing age-related bone loss and the associated risk of fractures but also for restoring bone mineral density to healthy levels.
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U2 - 10.1038/nrd3299
DO - 10.1038/nrd3299
M3 - Review article
C2 - 21283108
AN - SCOPUS:79551610971
SN - 1474-1776
VL - 10
SP - 141
EP - 156
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 2
ER -