Emerging techniques for elucidating mechanism of action of deep brain stimulation.

Kendall H Lee, Su-Youne Chang, Dong Pyo Jang, Inyong Kim, Stephan Goerss, Jamie Van Gompel, Paul Min, Kanika Arora, Michael Marsh, Sun Chul Hwang, Christopher J. Kimble, Paul Garris, Charles Blaha, Kevin E. Bennet

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) within the basal ganglia complex is an effective neurosurgical approach for treating symptoms of Parkinson's disease (PD), Essential Tremor, Dystonia, Depression, Obssessive Compulsive Disorder, and Tourette's Syndrome, among others. Elucidating DBS mechanism has become a critical clinical and research goal in stereotactic and functional neurosurgery and in neural engineering. Along with electro-physiological and microdialysis techniques, two additional powerful technologies, notably functional Magnetic Resonance Imaging (fMRI) and in vivo neurochemical monitoring have recently been used to investigate DBS-mediated activation of basal ganglia network circuitry. For this purpose, we have previously developed WINCS (Wireless Instantaneous Neurotransmitter Concentration Sensor System), which is an MRI-compatible wireless monitoring device to obtain chemically resolved neurotransmitter measurements at implanted microsensors in a large mammalian model (pig) as well as in human patients. This device supports an array of electrochemical measurements that includes fast-scan cyclic voltammetry (FSCV) for real-time simultaneous in vivo monitoring of dopamine and adenosine release at carbon-fiber microelectrodes as well as fixed potential amperometry for monitoring of glutamate at enzyme-linked biosensors. In addition, we have utilized fMRI to investigate subthalamic nucleus (STN) DBS activation in the pig with 3Tesla MR scanner. We demonstrate the activation of specific basal ganglia circuitry during STN DBS using both fMRI and FSCV in the pig model. Our results suggest that fMRI and electrochemistry are important emerging techniques for use in elucidating mechanism of action of DBS.

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Deep Brain Stimulation
Brain
Basal Ganglia
Magnetic Resonance Imaging
Subthalamic Nucleus
Swine
Monitoring
Chemical activation
Cyclic voltammetry
Neurotransmitter Agents
Neurosurgery
Essential Tremor
Electrochemistry
Tourette Syndrome
Equipment and Supplies
Microsensors
Dystonia
Microelectrodes
Microdialysis
Biosensing Techniques

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Emerging techniques for elucidating mechanism of action of deep brain stimulation. / Lee, Kendall H; Chang, Su-Youne; Jang, Dong Pyo; Kim, Inyong; Goerss, Stephan; Van Gompel, Jamie; Min, Paul; Arora, Kanika; Marsh, Michael; Hwang, Sun Chul; Kimble, Christopher J.; Garris, Paul; Blaha, Charles; Bennet, Kevin E.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Vol. 2011, 2011, p. 677-680.

Research output: Contribution to journalArticle

Lee, Kendall H ; Chang, Su-Youne ; Jang, Dong Pyo ; Kim, Inyong ; Goerss, Stephan ; Van Gompel, Jamie ; Min, Paul ; Arora, Kanika ; Marsh, Michael ; Hwang, Sun Chul ; Kimble, Christopher J. ; Garris, Paul ; Blaha, Charles ; Bennet, Kevin E. / Emerging techniques for elucidating mechanism of action of deep brain stimulation. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2011 ; Vol. 2011. pp. 677-680.
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