Emerging roles of urine-derived components for the management of bladder cancer: One man’s trash is another man’s treasure

Sarah Minkler; Fabrice Lucien; Michael J. Kimber; Dipak K. Sahoo; Agnes Bourgois-Mochel; Margaret Musser; Chad Johannes; Igor Frank; John Cheville; Karin Allenspach; Jonathan P. Mochel

doi:10.3390/cancers13030422

Emerging roles of urine-derived components for the management of bladder cancer: One man’s trash is another man’s treasure

Sarah Minkler, Fabrice Lucien, Michael J. Kimber, Dipak K. Sahoo, Agnes Bourgois-Mochel, Margaret Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, Jonathan P. Mochel

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

Original language	English (US)
Article number	422
Pages (from-to)	1-13
Number of pages	13
Journal	Cancers
Volume	13
Issue number	3
DOIs	https://doi.org/10.3390/cancers13030422
State	Published - 2021

Keywords

Bladder cancer
Exosomes
One health
Organoids
Precision medicine

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers13030422

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title = "Emerging roles of urine-derived components for the management of bladder cancer: One man{\textquoteright}s trash is another man{\textquoteright}s treasure",

abstract = "Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.",

keywords = "Bladder cancer, Exosomes, One health, Organoids, Precision medicine",

author = "Sarah Minkler and Fabrice Lucien and Kimber, {Michael J.} and Sahoo, {Dipak K.} and Agnes Bourgois-Mochel and Margaret Musser and Chad Johannes and Igor Frank and John Cheville and Karin Allenspach and Mochel, {Jonathan P.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/cancers13030422",

language = "English (US)",

volume = "13",

pages = "1--13",

journal = "Cancers",

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T2 - One man’s trash is another man’s treasure

AU - Minkler, Sarah

AU - Lucien, Fabrice

AU - Kimber, Michael J.

AU - Sahoo, Dipak K.

AU - Bourgois-Mochel, Agnes

AU - Musser, Margaret

AU - Johannes, Chad

AU - Frank, Igor

AU - Cheville, John

AU - Allenspach, Karin

AU - Mochel, Jonathan P.

PY - 2021

Y1 - 2021

N2 - Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

AB - Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

KW - Bladder cancer

KW - Exosomes

KW - One health

KW - Organoids

KW - Precision medicine

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U2 - 10.3390/cancers13030422

DO - 10.3390/cancers13030422

M3 - Review article

AN - SCOPUS:85099841232

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JO - Cancers

JF - Cancers

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M1 - 422

ER -

Emerging roles of urine-derived components for the management of bladder cancer: One man’s trash is another man’s treasure

Abstract

Keywords

ASJC Scopus subject areas

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