Emerging pharmacologic therapies for primary sclerosing cholangitis

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Purpose of review The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein. Recent findings Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic mechanisms largely extrapolated from ex-vivo and in-vivo preclinical models, as well as translational observations. Summary Future therapeutic strategies for PSC may include a multitude of complex pathogenic mechanisms encompassing pathways of immunomodulation, the microbiome and inflammation-related fibrosis.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalCurrent Opinion in Gastroenterology
Volume33
Issue number3
DOIs
StatePublished - May 1 2017

Keywords

  • bile acids
  • management
  • primary sclerosing cholangitis
  • therapies

ASJC Scopus subject areas

  • Gastroenterology

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