Emerging evidence of hepatitis C virus neuroinvasion

Tomasz Laskus, Marek Radkowski, Debra M. Adair, Jeffrey Wilkinson, Adrienne C. Scheck, Jorge Rakela

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

It has been reported that hepatitis C virus (HCV) infection is associated with cognitive dysfunction, fatigue and depression, which do not correlate with the severity of liver disease and cannot be accounted for by hepatic encephalopathy or drug abuse. There is also emerging evidence that HCV infection can have negative neurocognitive effects in HIV-infected cohorts. Magnetic resonance spectroscopy has suggested the likely existence of a biological basis for these effects. HCV replicative forms have recently been detected in autopsy brain tissue and the infected cells have been identified as CD68-positive (macrophages/microglia). These findings raise the possibility that HCV infection of the brain could be directly related to the reported neuropsychological and cognitive changes. HCV is not strictly hepatotropic, as it can also replicate in leukocytes, including monocytes/macrophages. The latter cells could provide access of HCV into the central nervous system ('Trojan horse' mechanism) in a process similar to that postulated for HIV-1. In support of this hypothetical mechanism come reports showing a close relationship between HCV sequences present in the brain and cerebrospinal fluid and sequences found in lymph nodes and peripheral blood mononuclear cells. However, despite some similarities there is a fundamental difference between HIV-1 and HCV infection as the latter does not progress into AIDS-type dementia.

Original languageEnglish (US)
JournalAIDS
Volume19
Issue numberSUPPL. 3
StatePublished - Oct 2005

Fingerprint

Hepacivirus
Virus Diseases
HIV-1
Brain
Macrophages
Hepatic Encephalopathy
Microglia
Substance-Related Disorders
Fatigue
Cerebrospinal Fluid
Dementia
Liver Diseases
Monocytes
Autopsy
Blood Cells
Acquired Immunodeficiency Syndrome
Leukocytes
Magnetic Resonance Spectroscopy
Central Nervous System
Lymph Nodes

Keywords

  • Central nervous system
  • HCV
  • HIV
  • Neurocognitive function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Laskus, T., Radkowski, M., Adair, D. M., Wilkinson, J., Scheck, A. C., & Rakela, J. (2005). Emerging evidence of hepatitis C virus neuroinvasion. AIDS, 19(SUPPL. 3).

Emerging evidence of hepatitis C virus neuroinvasion. / Laskus, Tomasz; Radkowski, Marek; Adair, Debra M.; Wilkinson, Jeffrey; Scheck, Adrienne C.; Rakela, Jorge.

In: AIDS, Vol. 19, No. SUPPL. 3, 10.2005.

Research output: Contribution to journalArticle

Laskus, T, Radkowski, M, Adair, DM, Wilkinson, J, Scheck, AC & Rakela, J 2005, 'Emerging evidence of hepatitis C virus neuroinvasion', AIDS, vol. 19, no. SUPPL. 3.
Laskus T, Radkowski M, Adair DM, Wilkinson J, Scheck AC, Rakela J. Emerging evidence of hepatitis C virus neuroinvasion. AIDS. 2005 Oct;19(SUPPL. 3).
Laskus, Tomasz ; Radkowski, Marek ; Adair, Debra M. ; Wilkinson, Jeffrey ; Scheck, Adrienne C. ; Rakela, Jorge. / Emerging evidence of hepatitis C virus neuroinvasion. In: AIDS. 2005 ; Vol. 19, No. SUPPL. 3.
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