Emergence of a STAT3 mutated NK clone in LGL leukemia

Yiyi Yan; Thomas L. Olson; Susan B. Nyland; David J. Feith; Thomas P. Loughran

doi:10.1016/j.lrr.2014.12.001

Emergence of a STAT3 mutated NK clone in LGL leukemia

Yiyi Yan, Thomas L. Olson, Susan B. Nyland, David J. Feith, Thomas P. Loughran

Medical Oncology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK but not T-cells in the mixed leukemic stage. Multiple, non-dominant T-cell clones with distinct STAT3 mutations were present throughout. Our results suggest that T and NK-LGL leukemia may share common pathogenesis mechanisms and that STAT3 mutation alone is insufficient to bring about clonal expansion. Mutational and immunological monitoring may provide diagnostic and therapeutic significance in LGL leukemia.

Original language	English (US)
Pages (from-to)	4-7
Number of pages	4
Journal	Leukemia Research Reports
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.lrr.2014.12.001
State	Published - Jan 1 2015

Keywords

Classifications
Clonal evolution
Leukemia markers
Mutation detection
T cell receptor

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2014.12.001

Cite this

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title = "Emergence of a STAT3 mutated NK clone in LGL leukemia",

abstract = "Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK but not T-cells in the mixed leukemic stage. Multiple, non-dominant T-cell clones with distinct STAT3 mutations were present throughout. Our results suggest that T and NK-LGL leukemia may share common pathogenesis mechanisms and that STAT3 mutation alone is insufficient to bring about clonal expansion. Mutational and immunological monitoring may provide diagnostic and therapeutic significance in LGL leukemia.",

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author = "Yiyi Yan and Olson, {Thomas L.} and Nyland, {Susan B.} and Feith, {David J.} and Loughran, {Thomas P.}",

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doi = "10.1016/j.lrr.2014.12.001",

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T1 - Emergence of a STAT3 mutated NK clone in LGL leukemia

AU - Yan, Yiyi

AU - Olson, Thomas L.

AU - Nyland, Susan B.

AU - Feith, David J.

AU - Loughran, Thomas P.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK but not T-cells in the mixed leukemic stage. Multiple, non-dominant T-cell clones with distinct STAT3 mutations were present throughout. Our results suggest that T and NK-LGL leukemia may share common pathogenesis mechanisms and that STAT3 mutation alone is insufficient to bring about clonal expansion. Mutational and immunological monitoring may provide diagnostic and therapeutic significance in LGL leukemia.

AB - Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK but not T-cells in the mixed leukemic stage. Multiple, non-dominant T-cell clones with distinct STAT3 mutations were present throughout. Our results suggest that T and NK-LGL leukemia may share common pathogenesis mechanisms and that STAT3 mutation alone is insufficient to bring about clonal expansion. Mutational and immunological monitoring may provide diagnostic and therapeutic significance in LGL leukemia.

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KW - Mutation detection

KW - T cell receptor

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Emergence of a STAT3 mutated NK clone in LGL leukemia

Abstract

Keywords

ASJC Scopus subject areas

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