EMERGEing progress in genomics-the first seven years

Dana C. Crawford; David R. Crosslin; Gerard Tromp; Iftikhar J. Kullo; Helena Kuivaniemi; M. Geoffrey Hayes; Joshua C. Denny; William S. Bush; Jonathan L. Haines; Dan M. Roden; Catherine A. McCarty; Gail P. Jarvik; Marylyn D. Ritchie

doi:10.3389/fgene.2014.00184

EMERGEing progress in genomics-the first seven years

Dana C. Crawford, David R. Crosslin, Gerard Tromp, Iftikhar J. Kullo, Helena Kuivaniemi, M. Geoffrey Hayes, Joshua C. Denny, William S. Bush, Jonathan L. Haines, Dan M. Roden, Catherine A. McCarty, Gail P. Jarvik, Marylyn D. Ritchie

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part to explore the utility of electronic medical records (EMRs) in genome science. The initial focus was on discovery primarily using the genome-wide association paradigm, but more recently, the network has begun evaluating mechanisms to implement new genomic information coupled to clinical decision support into EMRs. Herein, we describe this evolution including the development of the individual and merged eMERGE genomic datasets, the contribution the network has made toward genomic discovery and human health, and the steps taken toward the next generation genotype-phenotype association studies and clinical implementation.

Original language	English (US)
Article number	184
Journal	Frontiers in Genetics
Volume	5
Issue number	JUN
DOIs	https://doi.org/10.3389/fgene.2014.00184
State	Published - 2014

Keywords

Biobanks
Electronic medical records
Genome-wide association studies
Pharmacogenomics

ASJC Scopus subject areas

Molecular Medicine
Genetics
Genetics(clinical)

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10.3389/fgene.2014.00184

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title = "EMERGEing progress in genomics-the first seven years",

abstract = "The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part to explore the utility of electronic medical records (EMRs) in genome science. The initial focus was on discovery primarily using the genome-wide association paradigm, but more recently, the network has begun evaluating mechanisms to implement new genomic information coupled to clinical decision support into EMRs. Herein, we describe this evolution including the development of the individual and merged eMERGE genomic datasets, the contribution the network has made toward genomic discovery and human health, and the steps taken toward the next generation genotype-phenotype association studies and clinical implementation.",

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author = "Crawford, {Dana C.} and Crosslin, {David R.} and Gerard Tromp and Kullo, {Iftikhar J.} and Helena Kuivaniemi and Hayes, {M. Geoffrey} and Denny, {Joshua C.} and Bush, {William S.} and Haines, {Jonathan L.} and Roden, {Dan M.} and McCarty, {Catherine A.} and Jarvik, {Gail P.} and Ritchie, {Marylyn D.}",

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AU - Crosslin, David R.

AU - Tromp, Gerard

AU - Kullo, Iftikhar J.

AU - Kuivaniemi, Helena

AU - Hayes, M. Geoffrey

AU - Denny, Joshua C.

AU - Bush, William S.

AU - Haines, Jonathan L.

AU - Roden, Dan M.

AU - McCarty, Catherine A.

AU - Jarvik, Gail P.

AU - Ritchie, Marylyn D.

PY - 2014

Y1 - 2014

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KW - Electronic medical records

KW - Genome-wide association studies

KW - Pharmacogenomics

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EMERGEing progress in genomics-the first seven years

Abstract

Keywords

ASJC Scopus subject areas

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