Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate

Matthew T. Houdek; Kerryl E. Greenwood-Quaintance; Mark E. Morrey; Robin Patel; Arlen D. Hanssen

doi:10.1016/j.arth.2015.06.002

Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate

Matthew T. Houdek, Kerryl E. Greenwood-Quaintance, Mark E. Morrey, Robin Patel, Arlen D. Hanssen

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC_0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.

Original language	English (US)
Pages (from-to)	2308-2310
Number of pages	3
Journal	Journal of Arthroplasty
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.arth.2015.06.002
State	Published - Dec 1 2015

Keywords

Amphotericin
Cement spacer
Drug elution
Fungal infection
Prosthetic joint infection

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.arth.2015.06.002

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title = "Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate",

abstract = "Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.",

keywords = "Amphotericin, Cement spacer, Drug elution, Fungal infection, Prosthetic joint infection",

author = "Houdek, {Matthew T.} and Greenwood-Quaintance, {Kerryl E.} and Morrey, {Mark E.} and Robin Patel and Hanssen, {Arlen D.}",

year = "2015",

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doi = "10.1016/j.arth.2015.06.002",

language = "English (US)",

volume = "30",

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AU - Houdek, Matthew T.

AU - Greenwood-Quaintance, Kerryl E.

AU - Morrey, Mark E.

AU - Patel, Robin

AU - Hanssen, Arlen D.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.

AB - Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.

KW - Amphotericin

KW - Cement spacer

KW - Drug elution

KW - Fungal infection

KW - Prosthetic joint infection

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Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate

Abstract

Keywords

ASJC Scopus subject areas

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