Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate

Matthew T. Houdek, Kerryl E. Greenwood-Quaintance, Mark E. Morrey, Robin Patel, Arlen D. Hanssen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.

Original languageEnglish (US)
Pages (from-to)2308-2310
Number of pages3
JournalJournal of Arthroplasty
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Amphotericin
  • Cement spacer
  • Drug elution
  • Fungal infection
  • Prosthetic joint infection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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    Houdek, M. T., Greenwood-Quaintance, K. E., Morrey, M. E., Patel, R., & Hanssen, A. D. (2015). Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate. Journal of Arthroplasty, 30(12), 2308-2310. https://doi.org/10.1016/j.arth.2015.06.002