Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation

Eli Muchtar, Angela Dispenzieri, Martha Lacy, Francis K. Buadi, Prashant Kapoor, Suzanne R. Hayman, Wilson Gonsalves, Rahma Warsame, Taxiarchis Kourelis, Rajshekhar Chakraborty, Stephen J Russell, John A. Lust, Yi Lin, Ronald S. Go, Steven Zeldenrust, David M Dingli, Nelson Leung, S Vincent Rajkumar, Robert A. Kyle, Shaji K Kumar & 1 others Morie Gertz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.

Original languageEnglish (US)
JournalBritish Journal of Haematology
DOIs
StateAccepted/In press - 2017

Fingerprint

Stem Cell Transplantation
Amyloidosis
L-Lactate Dehydrogenase
Serum
Stem Cells
Transplants
Kidney
Light
Survival
Population

Keywords

  • Damage
  • Early death
  • Lactate dehydrogenase
  • Prognosis
  • Tissue

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation",
abstract = "The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40{\%} of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.",
keywords = "Damage, Early death, Lactate dehydrogenase, Prognosis, Tissue",
author = "Eli Muchtar and Angela Dispenzieri and Martha Lacy and Buadi, {Francis K.} and Prashant Kapoor and Hayman, {Suzanne R.} and Wilson Gonsalves and Rahma Warsame and Taxiarchis Kourelis and Rajshekhar Chakraborty and Russell, {Stephen J} and Lust, {John A.} and Yi Lin and Go, {Ronald S.} and Steven Zeldenrust and Dingli, {David M} and Nelson Leung and Rajkumar, {S Vincent} and Kyle, {Robert A.} and Kumar, {Shaji K} and Morie Gertz",
year = "2017",
doi = "10.1111/bjh.14830",
language = "English (US)",
journal = "British Journal of Haematology",
issn = "0007-1048",
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TY - JOUR

T1 - Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation

AU - Muchtar, Eli

AU - Dispenzieri, Angela

AU - Lacy, Martha

AU - Buadi, Francis K.

AU - Kapoor, Prashant

AU - Hayman, Suzanne R.

AU - Gonsalves, Wilson

AU - Warsame, Rahma

AU - Kourelis, Taxiarchis

AU - Chakraborty, Rajshekhar

AU - Russell, Stephen J

AU - Lust, John A.

AU - Lin, Yi

AU - Go, Ronald S.

AU - Zeldenrust, Steven

AU - Dingli, David M

AU - Leung, Nelson

AU - Rajkumar, S Vincent

AU - Kyle, Robert A.

AU - Kumar, Shaji K

AU - Gertz, Morie

PY - 2017

Y1 - 2017

N2 - The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.

AB - The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.

KW - Damage

KW - Early death

KW - Lactate dehydrogenase

KW - Prognosis

KW - Tissue

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