Elevating the Horizon: Emerging Molecular and Genomic Targets in the Treatment of Advanced Urothelial Carcinoma

Metin Kurtoglu, Nicole N. Davarpanah, Rui Qin, Thomas Powles, Jonathan E. Rosenberg, Andrea B. Apolo

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Despite recent advances in the identification of genomic alterations that lead to urothelial oncogenesis in vitro, patients with advanced urothelial carcinomas continue to have poor clinical outcomes. In the present review, we focus on targeted therapies that have yielded the most promising results alone or combined with traditional chemotherapy, including the antiangiogenesis agent bevacizumab, the human epidermal growth factor receptor 2 antibody trastuzumab, and the tyrosine kinase inhibitor cabozantinib. We also describe ongoing and developing clinical trials that use innovative approaches, including dose-dense scheduling of singular chemotherapy combinations, prospective screening of tumor tissues for mutational targets and biomarkers to predict chemosensitivity before the determination of the therapeutic regimen, and novel agents that target proteins in the immune checkpoint regulation pathway (programmed cell death protein 1 [PD-1] and anti-PD-ligand 1) that have shown significant potential in preclinical models and early clinical trials. New agents and targeted therapies, alone or combined with traditional chemotherapy, will only be validated through accrual to developing clinical trials that aim to translate these therapies into individualized treatments and improved survival rates in urothelial carcinoma.

Original languageEnglish (US)
Pages (from-to)410-420
Number of pages11
JournalClinical Genitourinary Cancer
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2015

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Keywords

  • Bladder cancer
  • Clinical trials
  • Immune checkpoints
  • Novel agents
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Urology

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