Elevated ventricular filling pressures and long-term survival in adults post-Fontan

William R. Miranda, Donald J. Hagler, Nathaniel W. Taggart, Barry A. Borlaug, Heidi M. Connolly, Alexander C. Egbe

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To assess the association between elevated ventricular-end diastolic pressures (VEDP) and pulmonary artery wedge pressure (PAWP) on long-term survival in adult Fontan patients. Background: The impact of ventricular filling pressures on long-term survival in adults post-Fontan palliation is unknown. Methods: We included 148 adult Fontan patients (age ≥ 18 years) without atrioventricular valve prosthesis or pulmonary vein stenosis undergoing arterial and venous catheterization between December 1999 and November 2017. VEDP was defined as ≥12 mmHg and PAWP as >12 mmHg based on optimal cut-offs for prediction of mortality on receiver-operator curves (AUC 0.63 and 0.66, respectively). Results: Mean age was 31.3 ± 9.2 years and 48.6% of patients were females. Most common congenital defects were tricuspid atresia (36.4%) and double-inlet left ventricle (28.3%); 59.5% patients had atriopulmonary Fontan connections. Mean VEDP was 11.5 ± 4.7 mmHg and PAWP 10.6 ± 4.5 mmHg (correlation coefficient.76). During a follow-up of 6.0 ± 4.8 years (median 5.4, IQR 1.4–9.4), there were 45 deaths (30.4%). Overall survival was lower in patients with VEDP ≥ 12 compared to those with VEDP < 12 mmHg (p =.02). Similarly, survival was lower in patients with PAWP>12 compared to patients with PAWP ≤ 12 mmHg (p <.0001). In the multivariate model, PAWP was an independent predictor of death (HR 1.1 per mmHg, 95% CI 1.02–1.15, p =.009) whereas VEDP was not (HR 1.1 per mmHg, 95% CI 1.0–1.13; p =.08). Conclusion: PAWP but not VEDP was independently associated with long-term overall mortality in adult Fontan patients. Perhaps PAWP rather than VEDP should be used in the risk stratification of these patients.

Original languageEnglish (US)
Pages (from-to)803-809
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Volume95
Issue number4
DOIs
StatePublished - Mar 1 2020

Keywords

  • Fontan palliation
  • hemodynamics
  • survival
  • ventricular filling pressures

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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