Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia

J. H. Butterfield, K. M. Leiferman, J. Abrams, J. E. Silver, J. Bower, N. Gonchoroff, G. J. Gleich

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Abstract

The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the percentage of activated T cells in the peripheral blood of a new patient before and during an attack. In the patient presented, IL-5 levels peaked several days before maximal eosinophilia and then declined. This patient's lymphocytes showed an increased percentage, 28% (normal 2% to 3%), of activated T cells staining for both CD3 and HLA-DR 10 days before maximal eosinophilia, but no increase at the time of peak eosinophilia. In serum from three previously reported cases, elevated serum IL-5 levels were found during attacks. After glucocorticoid administration, IL-5 levels became undetectable in three of the four patients. Production of IL-5 is likely an important determinant of the pathophysiology of this syndrome.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalBlood
Volume79
Issue number3
StatePublished - Feb 1 1992

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ASJC Scopus subject areas

  • Hematology

Cite this

Butterfield, J. H., Leiferman, K. M., Abrams, J., Silver, J. E., Bower, J., Gonchoroff, N., & Gleich, G. J. (1992). Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia. Blood, 79(3), 688-692.