Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants

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3 Citations (Scopus)

Abstract

Introduction: Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods: Tau-PET with AV-1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra-MTL abnormalities was determined. Left and right regions were compared within each subject. Results: Of CUs, 58% (334/576) had abnormal tau-PET findings. MTL abnormalities were present in 41% (238/576) of subjects. Discussion: MTL tau-PET signal is often associated with abnormal extra-MTL tau-PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau-PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P <.001) differences in tau–standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side-specific deficits.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume10
DOIs
StatePublished - Jan 1 2018

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Temporal Lobe
Alzheimer Disease
Brain
Neurofibrillary Tangles
Tomography
Population

Keywords

  • Alzheimer's disease
  • AV-1451
  • Cognitively normal
  • Imaging
  • Tau-PET

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{3beee714b1824e8eae0194d0b8b9a737,
title = "Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants",
abstract = "Introduction: Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods: Tau-PET with AV-1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra-MTL abnormalities was determined. Left and right regions were compared within each subject. Results: Of CUs, 58{\%} (334/576) had abnormal tau-PET findings. MTL abnormalities were present in 41{\%} (238/576) of subjects. Discussion: MTL tau-PET signal is often associated with abnormal extra-MTL tau-PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau-PET signal exclusively outside of the MTL is seen in 17{\%} of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P <.001) differences in tau–standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side-specific deficits.",
keywords = "Alzheimer's disease, AV-1451, Cognitively normal, Imaging, Tau-PET",
author = "Val Lowe and Bruinsma, {Tyler J.} and Min, {Hoon Ki} and Lundt, {Emily S.} and Ping Fang and Senjem, {Matthew L.} and Boeve, {Bradley F} and Josephs, {Keith Anthony} and Mukesh Pandey and Murray, {Melissa E} and Kantarci, {Kejal M} and Jones, {David T} and Christopher Schwarz and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.dadm.2018.01.005",
language = "English (US)",
volume = "10",
pages = "210--216",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
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TY - JOUR

T1 - Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants

AU - Lowe, Val

AU - Bruinsma, Tyler J.

AU - Min, Hoon Ki

AU - Lundt, Emily S.

AU - Fang, Ping

AU - Senjem, Matthew L.

AU - Boeve, Bradley F

AU - Josephs, Keith Anthony

AU - Pandey, Mukesh

AU - Murray, Melissa E

AU - Kantarci, Kejal M

AU - Jones, David T

AU - Schwarz, Christopher

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods: Tau-PET with AV-1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra-MTL abnormalities was determined. Left and right regions were compared within each subject. Results: Of CUs, 58% (334/576) had abnormal tau-PET findings. MTL abnormalities were present in 41% (238/576) of subjects. Discussion: MTL tau-PET signal is often associated with abnormal extra-MTL tau-PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau-PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P <.001) differences in tau–standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side-specific deficits.

AB - Introduction: Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods: Tau-PET with AV-1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra-MTL abnormalities was determined. Left and right regions were compared within each subject. Results: Of CUs, 58% (334/576) had abnormal tau-PET findings. MTL abnormalities were present in 41% (238/576) of subjects. Discussion: MTL tau-PET signal is often associated with abnormal extra-MTL tau-PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau-PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P <.001) differences in tau–standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side-specific deficits.

KW - Alzheimer's disease

KW - AV-1451

KW - Cognitively normal

KW - Imaging

KW - Tau-PET

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U2 - 10.1016/j.dadm.2018.01.005

DO - 10.1016/j.dadm.2018.01.005

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VL - 10

SP - 210

EP - 216

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

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