Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling

Yuichi Ninomiya, Shuichi Hamasaki, Sanemasa Ishida, Tetsuro Kataoka, Keishi Saihara, Hideki Okui, Koji Orihara, Tsuyoshi Fukudome, Takuro Shinsato, Tomoko Ichiki, Etsuko Mizoguchi, Yutaka Otsuji, Chuwa Tei

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Plasma levels of brain natriuretic peptide (BNP) correlate with left ventricular remodeling, but the relationship between BNP induction and coronary function remains unclear. Objectives. The present study assessed BNP production in response to left ventricular enlargement and investigated the relationship between BNP production and coronary vasodilating function in patients with left ventricular remodeling. Methods. Patients (« = 63) with normal or mildly diseased coronary arteries underwent Doppler flow study of the left anterior descending coronary artery. Vascular reactivity was examined using intracoronary acetylcholine, papaverine and nitroglycerin using a Doppler guidewire. Results. Left ventricular end-diastolic dimension, was positively correlated with BNP (r = 0.45, p< 0.001) in all patients. BNP was significantly and inversely correlated with percentage change in coronary artery diameter induced by acetylcholine (r = - 0.56, p < 0.001) but not by nitroglycerin (r - - 0.20, p = 0.28) in patients with left ventricular end-diastolic dimension ≥ 55 mm (n = 32). By contrast, BNP was not significantly correlated with percentage change in coronary artery diameter induced by either acetylcholine or nitroglycerin in patients with left ventricular end-diastolic dimension < 55mm( «= 31). Further, BNP was not correlated with the percentage change in coronary blood flow induced by acetylcholine or by papaverine in patients with or without left ventricular remodeling. Conclusions. The elevation in plasma BNP levels that occurs in association with left ventricular enlargement is a predictor of impaired endothelium-dependent vasodilation in conductance coronary arteries.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalJournal of Cardiology
Volume48
Issue number3
StatePublished - 2006
Externally publishedYes

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Ventricular Remodeling
Brain Natriuretic Peptide
Acetylcholine
Coronary Vessels
Nitroglycerin
Papaverine
Vasodilation
Endothelium
Blood Vessels
Coronary Artery Disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ninomiya, Y., Hamasaki, S., Ishida, S., Kataoka, T., Saihara, K., Okui, H., ... Tei, C. (2006). Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling. Journal of Cardiology, 48(3), 125-132.

Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling. / Ninomiya, Yuichi; Hamasaki, Shuichi; Ishida, Sanemasa; Kataoka, Tetsuro; Saihara, Keishi; Okui, Hideki; Orihara, Koji; Fukudome, Tsuyoshi; Shinsato, Takuro; Ichiki, Tomoko; Mizoguchi, Etsuko; Otsuji, Yutaka; Tei, Chuwa.

In: Journal of Cardiology, Vol. 48, No. 3, 2006, p. 125-132.

Research output: Contribution to journalArticle

Ninomiya, Y, Hamasaki, S, Ishida, S, Kataoka, T, Saihara, K, Okui, H, Orihara, K, Fukudome, T, Shinsato, T, Ichiki, T, Mizoguchi, E, Otsuji, Y & Tei, C 2006, 'Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling', Journal of Cardiology, vol. 48, no. 3, pp. 125-132.
Ninomiya, Yuichi ; Hamasaki, Shuichi ; Ishida, Sanemasa ; Kataoka, Tetsuro ; Saihara, Keishi ; Okui, Hideki ; Orihara, Koji ; Fukudome, Tsuyoshi ; Shinsato, Takuro ; Ichiki, Tomoko ; Mizoguchi, Etsuko ; Otsuji, Yutaka ; Tei, Chuwa. / Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling. In: Journal of Cardiology. 2006 ; Vol. 48, No. 3. pp. 125-132.
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abstract = "Background. Plasma levels of brain natriuretic peptide (BNP) correlate with left ventricular remodeling, but the relationship between BNP induction and coronary function remains unclear. Objectives. The present study assessed BNP production in response to left ventricular enlargement and investigated the relationship between BNP production and coronary vasodilating function in patients with left ventricular remodeling. Methods. Patients (« = 63) with normal or mildly diseased coronary arteries underwent Doppler flow study of the left anterior descending coronary artery. Vascular reactivity was examined using intracoronary acetylcholine, papaverine and nitroglycerin using a Doppler guidewire. Results. Left ventricular end-diastolic dimension, was positively correlated with BNP (r = 0.45, p< 0.001) in all patients. BNP was significantly and inversely correlated with percentage change in coronary artery diameter induced by acetylcholine (r = - 0.56, p < 0.001) but not by nitroglycerin (r - - 0.20, p = 0.28) in patients with left ventricular end-diastolic dimension ≥ 55 mm (n = 32). By contrast, BNP was not significantly correlated with percentage change in coronary artery diameter induced by either acetylcholine or nitroglycerin in patients with left ventricular end-diastolic dimension < 55mm( «= 31). Further, BNP was not correlated with the percentage change in coronary blood flow induced by acetylcholine or by papaverine in patients with or without left ventricular remodeling. Conclusions. The elevation in plasma BNP levels that occurs in association with left ventricular enlargement is a predictor of impaired endothelium-dependent vasodilation in conductance coronary arteries.",
author = "Yuichi Ninomiya and Shuichi Hamasaki and Sanemasa Ishida and Tetsuro Kataoka and Keishi Saihara and Hideki Okui and Koji Orihara and Tsuyoshi Fukudome and Takuro Shinsato and Tomoko Ichiki and Etsuko Mizoguchi and Yutaka Otsuji and Chuwa Tei",
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T1 - Elevated levels of brain natriuretic peptide as a predictor of impaired coronary endothelial function in patients with left ventricular remodeling

AU - Ninomiya, Yuichi

AU - Hamasaki, Shuichi

AU - Ishida, Sanemasa

AU - Kataoka, Tetsuro

AU - Saihara, Keishi

AU - Okui, Hideki

AU - Orihara, Koji

AU - Fukudome, Tsuyoshi

AU - Shinsato, Takuro

AU - Ichiki, Tomoko

AU - Mizoguchi, Etsuko

AU - Otsuji, Yutaka

AU - Tei, Chuwa

PY - 2006

Y1 - 2006

N2 - Background. Plasma levels of brain natriuretic peptide (BNP) correlate with left ventricular remodeling, but the relationship between BNP induction and coronary function remains unclear. Objectives. The present study assessed BNP production in response to left ventricular enlargement and investigated the relationship between BNP production and coronary vasodilating function in patients with left ventricular remodeling. Methods. Patients (« = 63) with normal or mildly diseased coronary arteries underwent Doppler flow study of the left anterior descending coronary artery. Vascular reactivity was examined using intracoronary acetylcholine, papaverine and nitroglycerin using a Doppler guidewire. Results. Left ventricular end-diastolic dimension, was positively correlated with BNP (r = 0.45, p< 0.001) in all patients. BNP was significantly and inversely correlated with percentage change in coronary artery diameter induced by acetylcholine (r = - 0.56, p < 0.001) but not by nitroglycerin (r - - 0.20, p = 0.28) in patients with left ventricular end-diastolic dimension ≥ 55 mm (n = 32). By contrast, BNP was not significantly correlated with percentage change in coronary artery diameter induced by either acetylcholine or nitroglycerin in patients with left ventricular end-diastolic dimension < 55mm( «= 31). Further, BNP was not correlated with the percentage change in coronary blood flow induced by acetylcholine or by papaverine in patients with or without left ventricular remodeling. Conclusions. The elevation in plasma BNP levels that occurs in association with left ventricular enlargement is a predictor of impaired endothelium-dependent vasodilation in conductance coronary arteries.

AB - Background. Plasma levels of brain natriuretic peptide (BNP) correlate with left ventricular remodeling, but the relationship between BNP induction and coronary function remains unclear. Objectives. The present study assessed BNP production in response to left ventricular enlargement and investigated the relationship between BNP production and coronary vasodilating function in patients with left ventricular remodeling. Methods. Patients (« = 63) with normal or mildly diseased coronary arteries underwent Doppler flow study of the left anterior descending coronary artery. Vascular reactivity was examined using intracoronary acetylcholine, papaverine and nitroglycerin using a Doppler guidewire. Results. Left ventricular end-diastolic dimension, was positively correlated with BNP (r = 0.45, p< 0.001) in all patients. BNP was significantly and inversely correlated with percentage change in coronary artery diameter induced by acetylcholine (r = - 0.56, p < 0.001) but not by nitroglycerin (r - - 0.20, p = 0.28) in patients with left ventricular end-diastolic dimension ≥ 55 mm (n = 32). By contrast, BNP was not significantly correlated with percentage change in coronary artery diameter induced by either acetylcholine or nitroglycerin in patients with left ventricular end-diastolic dimension < 55mm( «= 31). Further, BNP was not correlated with the percentage change in coronary blood flow induced by acetylcholine or by papaverine in patients with or without left ventricular remodeling. Conclusions. The elevation in plasma BNP levels that occurs in association with left ventricular enlargement is a predictor of impaired endothelium-dependent vasodilation in conductance coronary arteries.

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