TY - JOUR
T1 - Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinoma
AU - Qin, Hai De
AU - Jia, Wei Hua
AU - Zhang, Lin Lin
AU - Liu, Na
AU - Zhou, Xin Xi
AU - Wang, Ming Hsi
AU - Feng, Qi Sheng
AU - Chen, Li Zhen
AU - Zhang, Ying
AU - Jorgensen, Timothy J.
AU - Zeng, Yi Xin
AU - Shugart, Yin Yao
PY - 2011/10
Y1 - 2011/10
N2 - Serum antibodies to Epstein-Barr virus (EBV) antigens can be used to predict the risk of nasopharyngeal carcinoma (NPC). To investigate whether EBV seropositivity rates were higher among healthy family members from multiplex and sporadic families with NPC (i.e., families with multiple or single cases) compared to the general population, a study was conducted on 2,665 unaffected individuals from 140 multiplex and 413 sporadic families. The titers of the IgA antibody to the EBV capsid antigen (VCA-IgA) were compared to those of 904 controls from the general population. The VCA-IgA titer was correlated among sibling pairs to a high significance in both family types (P<0.0001 and P=0.0005 for the multiplex and the sporadic families, respectively); parent-offspring pairs also showed significant correlation (P<0.0001 and P=0.0002, respectively); and spouse pairs were correlated, but at lower significance levels (P=0.0790 and P=0.0040, respectively). When compared to the controls, among first-degree relatives in the multiplex families, the age- and gender-adjusted odds ratio (OR) was 2.06 (95% confidence interval 1.56-2.71), 3.55 (2.24-5.64), and 2.25 (1.57-3.23) for siblings, parents, and children, respectively. In the sporadic families, the adjusted OR was 1.55 (1.21-2.00) and 2.08 (1.51-2.86) for siblings and parents, respectively. The adjusted P-value of spouses lost significance in the multiplex families, but remained significant in the sporadic families (P=0.0146). In conclusion, EBV seropositivity rates were elevated among unaffected family members in both multiplex and sporadic families with NPC.
AB - Serum antibodies to Epstein-Barr virus (EBV) antigens can be used to predict the risk of nasopharyngeal carcinoma (NPC). To investigate whether EBV seropositivity rates were higher among healthy family members from multiplex and sporadic families with NPC (i.e., families with multiple or single cases) compared to the general population, a study was conducted on 2,665 unaffected individuals from 140 multiplex and 413 sporadic families. The titers of the IgA antibody to the EBV capsid antigen (VCA-IgA) were compared to those of 904 controls from the general population. The VCA-IgA titer was correlated among sibling pairs to a high significance in both family types (P<0.0001 and P=0.0005 for the multiplex and the sporadic families, respectively); parent-offspring pairs also showed significant correlation (P<0.0001 and P=0.0002, respectively); and spouse pairs were correlated, but at lower significance levels (P=0.0790 and P=0.0040, respectively). When compared to the controls, among first-degree relatives in the multiplex families, the age- and gender-adjusted odds ratio (OR) was 2.06 (95% confidence interval 1.56-2.71), 3.55 (2.24-5.64), and 2.25 (1.57-3.23) for siblings, parents, and children, respectively. In the sporadic families, the adjusted OR was 1.55 (1.21-2.00) and 2.08 (1.51-2.86) for siblings and parents, respectively. The adjusted P-value of spouses lost significance in the multiplex families, but remained significant in the sporadic families (P=0.0146). In conclusion, EBV seropositivity rates were elevated among unaffected family members in both multiplex and sporadic families with NPC.
KW - Epstein-Barr virus
KW - Familial correlation
KW - Multiplex and sporadic families
KW - Nasopharyngeal carcinoma
KW - Seroreactivity
UR - http://www.scopus.com/inward/record.url?scp=80051583075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051583075&partnerID=8YFLogxK
U2 - 10.1002/jmv.22121
DO - 10.1002/jmv.22121
M3 - Article
C2 - 21837797
AN - SCOPUS:80051583075
SN - 0146-6615
VL - 83
SP - 1792
EP - 1798
JO - Journal of medical virology
JF - Journal of medical virology
IS - 10
ER -