Electrophysiology of neurones of the inferior mesenteric ganglion of the cat

Y. Jule, J. H. Szurszewski

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Abstract

Intracellular recordings were obtained from cells in vitro in the inferior mesenteric ganglia of the cat. Neurones could be classified into three types: non-spontaneous, irregular discharging and regular discharging neurones. Non-spontaneous neurones had a stable resting membrane potential and responded with action potentials to indirect preganglionic nerve stimulation and to intracellular injection of depolarizing current. Irregular discharging neurones were characterized by a discharge of excitatory post-synaptic potentials (e.p.s.p.s.) which sometimes gave rise to action potentials. This activity was abolished by hexamethonium bromide, chlorisondamine and d-tubocurarine chloride. Tetrodotoxin and a low Ca2+-high Mg2+ solution also blocked on-going activity in irregular discharging neurones. Regular discharging neurones were characterized by a rhythmic discharge of action potentials. Each action potential was preceded by a gradual depolarization of the intracellularly recorded membrane potential. Intracellular injection of hyperpolarizing current abolished the regular discharge of action potential. No synaptic potentials were observed during hyperpolarization of the membrane potential. Nicotinic, muscarinic and adrenergic receptor blocking drugs did not modify the discharge of action potentials in regular discharging neurones. A low Ca2+-high Mg2+ solution also had no effect on the regular discharge of action potentials. Interpolation of an action potential between spontaneous action potentials in regular discharging neurones reset the rhythm of discharge. It is suggested that regular discharging neurones were endogenously active and that these neurones provided synaptic input to irregular discharging neurones.

Original languageEnglish (US)
Pages (from-to)277-292
Number of pages16
JournalJournal of Physiology
VolumeVOL. 344
StatePublished - 1983

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Electrophysiology
Ganglia
Cats
Action Potentials
Neurons
Membrane Potentials
Tubocurarine
Synaptic Potentials
Chlorisondamine
Hexamethonium
Injections
Tetrodotoxin
Nicotinic Receptors
Muscarinic Receptors
Adrenergic Receptors

ASJC Scopus subject areas

  • Physiology

Cite this

Electrophysiology of neurones of the inferior mesenteric ganglion of the cat. / Jule, Y.; Szurszewski, J. H.

In: Journal of Physiology, Vol. VOL. 344, 1983, p. 277-292.

Research output: Contribution to journalArticle

Jule, Y & Szurszewski, JH 1983, 'Electrophysiology of neurones of the inferior mesenteric ganglion of the cat', Journal of Physiology, vol. VOL. 344, pp. 277-292.
Jule, Y. ; Szurszewski, J. H. / Electrophysiology of neurones of the inferior mesenteric ganglion of the cat. In: Journal of Physiology. 1983 ; Vol. VOL. 344. pp. 277-292.
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