Electrophysiological studies on the effect of age on caudal nerve of the rat

James D. Schmelzer; Phillip A. Low

doi:10.1016/0014-4886(87)90223-8

Electrophysiological studies on the effect of age on caudal nerve of the rat

James D. Schmelzer, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The effect of age on electrophysiologic parameters was studied on the caudal nerve of 374 male Sprague-Dawley rats (age 24 to 630 days) and on 83 Fischer 344 rats (age 29 to 900 days). For Sprague-Dawley rats nerve conduction velocity and nerve action potential amplitude were both a parabolic function of age, increasing to 1 year and then declining. For Fischer 344 rats the same parameters increased progressively to 1.5 years and then declined. In contrast, for both Sprague-Dawley and Fischer 344 rats, resistance to ischemic conduction failure was a hyperbolic function of age reaching an asymptote at 1.5 to 2 years of age. These age-related changes in caudal nerve parallel the electrophysiologic alterations with age in human peripheral nerve more closely than previous reports in rodent limb nerves.

Original language	English (US)
Pages (from-to)	612-620
Number of pages	9
Journal	Experimental Neurology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(87)90223-8
State	Published - Jun 1987

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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@article{c3fc9535209343e7953fb26aca0e09e2,

title = "Electrophysiological studies on the effect of age on caudal nerve of the rat",

abstract = "The effect of age on electrophysiologic parameters was studied on the caudal nerve of 374 male Sprague-Dawley rats (age 24 to 630 days) and on 83 Fischer 344 rats (age 29 to 900 days). For Sprague-Dawley rats nerve conduction velocity and nerve action potential amplitude were both a parabolic function of age, increasing to 1 year and then declining. For Fischer 344 rats the same parameters increased progressively to 1.5 years and then declined. In contrast, for both Sprague-Dawley and Fischer 344 rats, resistance to ischemic conduction failure was a hyperbolic function of age reaching an asymptote at 1.5 to 2 years of age. These age-related changes in caudal nerve parallel the electrophysiologic alterations with age in human peripheral nerve more closely than previous reports in rodent limb nerves.",

author = "Schmelzer, {James D.} and Low, {Phillip A.}",

note = "Funding Information: Abbreviations: NAP-nerve action potential, NCV-nerve conduction velocity, RICF-resistance to ischemic conduction failure, S-D-Sprague-Dawley. {\textquoteright} This work was supported in part by grants from the National Institutes of Health (ROl NS22352, NS14304), the Muscular Dystrophy Association of America, and the Mayo and Mogg Funds.",

year = "1987",

month = jun,

doi = "10.1016/0014-4886(87)90223-8",

language = "English (US)",

volume = "96",

pages = "612--620",

journal = "Experimental Neurology",

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T1 - Electrophysiological studies on the effect of age on caudal nerve of the rat

AU - Schmelzer, James D.

AU - Low, Phillip A.

N1 - Funding Information: Abbreviations: NAP-nerve action potential, NCV-nerve conduction velocity, RICF-resistance to ischemic conduction failure, S-D-Sprague-Dawley. ’ This work was supported in part by grants from the National Institutes of Health (ROl NS22352, NS14304), the Muscular Dystrophy Association of America, and the Mayo and Mogg Funds.

PY - 1987/6

Y1 - 1987/6

N2 - The effect of age on electrophysiologic parameters was studied on the caudal nerve of 374 male Sprague-Dawley rats (age 24 to 630 days) and on 83 Fischer 344 rats (age 29 to 900 days). For Sprague-Dawley rats nerve conduction velocity and nerve action potential amplitude were both a parabolic function of age, increasing to 1 year and then declining. For Fischer 344 rats the same parameters increased progressively to 1.5 years and then declined. In contrast, for both Sprague-Dawley and Fischer 344 rats, resistance to ischemic conduction failure was a hyperbolic function of age reaching an asymptote at 1.5 to 2 years of age. These age-related changes in caudal nerve parallel the electrophysiologic alterations with age in human peripheral nerve more closely than previous reports in rodent limb nerves.

AB - The effect of age on electrophysiologic parameters was studied on the caudal nerve of 374 male Sprague-Dawley rats (age 24 to 630 days) and on 83 Fischer 344 rats (age 29 to 900 days). For Sprague-Dawley rats nerve conduction velocity and nerve action potential amplitude were both a parabolic function of age, increasing to 1 year and then declining. For Fischer 344 rats the same parameters increased progressively to 1.5 years and then declined. In contrast, for both Sprague-Dawley and Fischer 344 rats, resistance to ischemic conduction failure was a hyperbolic function of age reaching an asymptote at 1.5 to 2 years of age. These age-related changes in caudal nerve parallel the electrophysiologic alterations with age in human peripheral nerve more closely than previous reports in rodent limb nerves.

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Electrophysiological studies on the effect of age on caudal nerve of the rat

Abstract

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