Electrophysiological findings in a cohort of old polio survivors

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A population-based cohort of poliomyelitis survivors was established and followed for 15 years (mean time since polio was 40 years). Over time, the cohort demonstrated a modest decline in summated compound muscle action potential amplitudes (CMAP) and a moderate decline in the summated motor unit number estimates (MUNE). There was no association between symptoms of late deterioration and magnitude of decline. Rather, the presence of these symptoms was associated with the magnitude of the residual deficits. Two patterns of neuron loss were modeled (linear and proportional decline). The summated MUNE was a more sensitive measure of loss of motor units than was the summated CMAP and appears to be a more valid measure of attritional loss of anterior horn cells. Of these two models of neuron loss, the proportional loss of motor neurons was a better fit of the data than a linear loss.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of the Peripheral Nervous System
Volume11
Issue number3
DOIs
StatePublished - Sep 2006

Fingerprint

Poliomyelitis
Action Potentials
Anterior Horn Cells
Neurons
Muscles
Motor Neurons
Population

Keywords

  • Electrophysiology
  • Epidemiology
  • Neuromuscular disease
  • Poliomyelitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Electrophysiological findings in a cohort of old polio survivors. / Sorenson, Eric James; Daube, Jasper R.; Windebank, Anthony John.

In: Journal of the Peripheral Nervous System, Vol. 11, No. 3, 09.2006, p. 241-246.

Research output: Contribution to journalArticle

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