TY - JOUR
T1 - Electromechanical Activation Sequence in Normal Heart
AU - Sengupta, Partho P.
AU - Tondato, Fernando
AU - Khandheria, Bijoy K.
AU - Belohlavek, Marek
AU - Jahangir, Arshad
PY - 2008/7/1
Y1 - 2008/7/1
N2 - This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.
AB - This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.
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U2 - 10.1016/j.hfc.2008.02.006
DO - 10.1016/j.hfc.2008.02.006
M3 - Review article
C2 - 18598982
AN - SCOPUS:45849146967
VL - 4
SP - 303
EP - 314
JO - Heart Failure Clinics
JF - Heart Failure Clinics
SN - 1551-7136
IS - 3
ER -