Abstract
This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 303-314 |
| Number of pages | 12 |
| Journal | Heart Failure Clinics |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2008 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Electromechanical Activation Sequence in Normal Heart. / Sengupta, Partho P.; Tondato, Fernando; Khandheria, Bijoy K.; Belohlavek, Marek; Jahangir, Arshad.
In: Heart Failure Clinics, Vol. 4, No. 3, 07.2008, p. 303-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electromechanical Activation Sequence in Normal Heart
AU - Sengupta, Partho P.
AU - Tondato, Fernando
AU - Khandheria, Bijoy K.
AU - Belohlavek, Marek
AU - Jahangir, Arshad
PY - 2008/7
Y1 - 2008/7
N2 - This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.
AB - This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.
UR - http://www.scopus.com/inward/record.url?scp=45849146967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849146967&partnerID=8YFLogxK
U2 - 10.1016/j.hfc.2008.02.006
DO - 10.1016/j.hfc.2008.02.006
M3 - Article
VL - 4
SP - 303
EP - 314
JO - Heart Failure Clinics
JF - Heart Failure Clinics
SN - 1551-7136
IS - 3
ER -