Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure

Tsering Dhondup, Qi Qian

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The kidneys play a pivotal role in the regulation of electrolyte and acid-base balance. With progressive loss of kidney function, derangements in electrolytes and acid-base inevitably occur and contribute to poor patient outcomes. As chronic kidney disease (CKD) has become a worldwide epidemic, medical providers are increasingly confronted with such problems. Adequate diagnosis and treatment will minimize complications and can potentially be lifesaving. In this review, we discuss the current understanding of the disease process, clinical presentation, diagnosis and treatment strategies, integrating up-to-date knowledge in the field. Although electrolyte and acid-base derangements are significant causes of morbidity and mortality in CKD and end-stage renal disease patients, they can be effectively managed through a timely institution of combined preventive measures and pharmacological therapy. Exciting advances and several upcoming outcome trials will provide further information to guide treatment and improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalBlood Purification
Volume43
Issue number1-3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Chronic Renal Insufficiency
Electrolytes
Renal Insufficiency
Acids
Kidney
Acid-Base Equilibrium
Therapeutics
Chronic Kidney Failure
Pharmacology
Morbidity
Mortality

Keywords

  • Acidosis
  • Chronic kidney disease
  • Dyskalemia
  • Dysmagnesemia
  • Dysnatremia
  • End-stage renal disease
  • Mineral bone disorder

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure. / Dhondup, Tsering; Qian, Qi.

In: Blood Purification, Vol. 43, No. 1-3, 01.03.2017, p. 179-188.

Research output: Contribution to journalReview article

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