Electroencephalography in primary progressive aphasia and apraxia of speech

Research output: Contribution to journalArticle

Abstract

Background: Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied. Aims: The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/agrammatic variant of PPA (agPPA) and PPAOS. Methods and Procedures: Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis. Outcomes and Results: Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations. Conclusions: This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.

Original languageEnglish (US)
JournalAphasiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Primary Progressive Aphasia
Apraxias
speech disorder
Electroencephalography
Aphasia
Magnetic Resonance Imaging
examiner
Apraxia of Speech
Consensus
Biomarkers
recording
Head
Costs and Cost Analysis
expert
examination
Research

Keywords

  • electroencephalography (EEG)
  • Frontotemporal dementia
  • primary progressive aphasia
  • primary progressive apraxia of speech

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Language and Linguistics
  • Developmental and Educational Psychology
  • Linguistics and Language
  • Neurology
  • Clinical Neurology
  • LPN and LVN

Cite this

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title = "Electroencephalography in primary progressive aphasia and apraxia of speech",
abstract = "Background: Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied. Aims: The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/agrammatic variant of PPA (agPPA) and PPAOS. Methods and Procedures: Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis. Outcomes and Results: Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations. Conclusions: This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.",
keywords = "electroencephalography (EEG), Frontotemporal dementia, primary progressive aphasia, primary progressive apraxia of speech",
author = "Rene Utianski and Caviness, {John Nathaniel} and Worrell, {Gregory Alan} and Duffy, {Joseph R.} and Heather Clark and Machulda, {Mary Margaret} and Whitwell, {Jennifer Lynn} and Josephs, {Keith Anthony}",
year = "2018",
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doi = "10.1080/02687038.2018.1545991",
language = "English (US)",
journal = "Aphasiology",
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AU - Utianski, Rene

AU - Caviness, John Nathaniel

AU - Worrell, Gregory Alan

AU - Duffy, Joseph R.

AU - Clark, Heather

AU - Machulda, Mary Margaret

AU - Whitwell, Jennifer Lynn

AU - Josephs, Keith Anthony

PY - 2018/1/1

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N2 - Background: Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied. Aims: The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/agrammatic variant of PPA (agPPA) and PPAOS. Methods and Procedures: Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis. Outcomes and Results: Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations. Conclusions: This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.

AB - Background: Past research has demonstrated that electroencephalography (EEG) is sensitive to what we now know as Primary Progressive Aphasia (PPA); however, the EEG profiles of patients with Primary Progressive Apraxia of Speech (PPAOS) and PPA, in the context of current consensus criteria, have not been studied. Aims: The primary goal of this study was to explore the EEG profiles of patients of the nonfluent/agrammatic variant of PPA (agPPA) and PPAOS. Methods and Procedures: Three patients with agPPA and five patients with PPAOS (two with aphasia) completed a head MRI scan and clinical EEG recording. Clinical radiologists and electrophysiologists reviewed respective imaging, blinded to clinical diagnosis. Outcomes and Results: Patients with PPAOS who did not have aphasia had normal EEGs, while those with aphasia demonstrated theta slowing. Patients with agPPA also showed theta slowing, with one exception. MRI scans showed non-specific, age-related changes across clinical presentations. Conclusions: This preliminary study suggests theta slowing is consistent with neurodegenerative aphasia, but not isolated apraxia of speech. EEG is a low-cost mechanism to identify possible biomarkers for use when clinical severity limits behavioral examinations or expert examiners are unavailable.

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