Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD

long-term 3-year results

Leonardo Rodríguez, Patricia A. Rodriguez, Beatrice Gómez, Manoel Galvao Netto, Michael D. Crowell, Edy Soffer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with % 24-h esophageal pH <4.0 for >5 %, with hiatal hernia 50 % of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.

Original languageEnglish (US)
JournalSurgical Endoscopy and Other Interventional Techniques
DOIs
StateAccepted/In press - Oct 20 2015

Fingerprint

Electric Stimulation Therapy
Lower Esophageal Sphincter
Gastroesophageal Reflux
Hiatal Hernia
Electric Stimulation
Safety
Equipment and Supplies
Acids

Keywords

  • Electrical stimulation
  • Esophageal acid
  • GERD
  • Lower esophageal sphincter
  • Outcomes
  • Treatment

ASJC Scopus subject areas

  • Surgery

Cite this

Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD : long-term 3-year results. / Rodríguez, Leonardo; Rodriguez, Patricia A.; Gómez, Beatrice; Netto, Manoel Galvao; Crowell, Michael D.; Soffer, Edy.

In: Surgical Endoscopy and Other Interventional Techniques, 20.10.2015.

Research output: Contribution to journalArticle

Rodríguez, Leonardo ; Rodriguez, Patricia A. ; Gómez, Beatrice ; Netto, Manoel Galvao ; Crowell, Michael D. ; Soffer, Edy. / Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD : long-term 3-year results. In: Surgical Endoscopy and Other Interventional Techniques. 2015.
@article{22d180965b904a1db0036d427cbba586,
title = "Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: long-term 3-year results",
abstract = "Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with {\%} 24-h esophageal pH <4.0 for >5 {\%}, with hiatal hernia 50 {\%} of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.",
keywords = "Electrical stimulation, Esophageal acid, GERD, Lower esophageal sphincter, Outcomes, Treatment",
author = "Leonardo Rodr{\'i}guez and Rodriguez, {Patricia A.} and Beatrice G{\'o}mez and Netto, {Manoel Galvao} and Crowell, {Michael D.} and Edy Soffer",
year = "2015",
month = "10",
day = "20",
doi = "10.1007/s00464-015-4539-5",
language = "English (US)",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York",

}

TY - JOUR

T1 - Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD

T2 - long-term 3-year results

AU - Rodríguez, Leonardo

AU - Rodriguez, Patricia A.

AU - Gómez, Beatrice

AU - Netto, Manoel Galvao

AU - Crowell, Michael D.

AU - Soffer, Edy

PY - 2015/10/20

Y1 - 2015/10/20

N2 - Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with % 24-h esophageal pH <4.0 for >5 %, with hiatal hernia 50 % of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.

AB - Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with % 24-h esophageal pH <4.0 for >5 %, with hiatal hernia 50 % of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.

KW - Electrical stimulation

KW - Esophageal acid

KW - GERD

KW - Lower esophageal sphincter

KW - Outcomes

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84944930974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944930974&partnerID=8YFLogxK

U2 - 10.1007/s00464-015-4539-5

DO - 10.1007/s00464-015-4539-5

M3 - Article

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

ER -