Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: long-term 3-year results

Leonardo Rodríguez, Patricia A. Rodriguez, Beatrice Gómez, Manoel Galvao Netto, Michael D. Crowell, Edy Soffer

Research output: Contribution to journalArticle

15 Scopus citations


Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with % 24-h esophageal pH <4.0 for >5 %, with hiatal hernia 50 % of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.

Original languageEnglish (US)
JournalSurgical Endoscopy and Other Interventional Techniques
StateAccepted/In press - Oct 20 2015



  • Electrical stimulation
  • Esophageal acid
  • GERD
  • Lower esophageal sphincter
  • Outcomes
  • Treatment

ASJC Scopus subject areas

  • Surgery

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