Background: Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2 years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3 years. Methods: GERD patients with partial response to PPI, with % 24-h esophageal pH <4.0 for >5 %, with hiatal hernia 50 % of days with PPI use); three had normal esophageal pH at 3 years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up. Conclusion: LES-EST is safe and effective for treating patients with GERD over long-term, 3-year duration. There was a significant and sustained improvement in esophageal acid exposure and reduction in GERD symptoms and PPI use. Further, no new GI side effects or adverse events were reported.
|Original language||English (US)|
|Journal||Surgical Endoscopy and Other Interventional Techniques|
|State||Accepted/In press - Oct 20 2015|
- Electrical stimulation
- Esophageal acid
- Lower esophageal sphincter
ASJC Scopus subject areas