Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography

Akihiko Kandori, Tsuyoshi Miyashita, Kuniomi Ogata, Wataru Shimizu, Miki Yokokawa, Shiro Kamakura, Kunio Miyatake, Keiji Tsukada, Satsuki Yamada, Shigeyuki Watanabe, Iwao Yamaguchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Both ventricular depolarization abnormalities (QRS complex) and repolarization ones (ST/T) are still controversial in literature. The objective of this study was to clarify the space-time variations that occur in patients carriers of Brugada syndrome using Magnetocardiography and also compare them with cases of complete right-bundle branch block (CRBBB) and individuals without any dromotropic disorder (control group). Methods and Results: Magnetocardiograms (MCGs) of Brugada syndrome patients (n = 16), CRBBB patients (n = 14), and members of a control group (n = 46) at rest were recorded. The MCGs were used to produce a whole-heart electrical-activation diagram (W-HEAD), which can visualize the spatial time-variant activation in the whole heart. In the W-HEAD pattern, three activations were located in the left ventricle, and CRBBB patients had a wide peak with about 65-ms delay on the right anterior side. While the Brugada syndrome pattern has a posteromedian left-ventricle excitation, that is half the amplitude that occurs in CRBBB patients, the electrical conduction rate to the posterosuperior septum area was low. Conclusions: The W-HEAD data made it possible to visualize space-time depolarization abnormalities. These findings suggest that the electrical conduction rate to the posterosuperior septum area in Brugada syndrome cases is low, and this low activation may be a feature of typical Brugada syndrome.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume29
Issue number1
DOIs
StatePublished - Jan 2006

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Magnetocardiography
Brugada Syndrome
Bundle-Branch Block
Heart Ventricles
Control Groups

Keywords

  • Arrhythmia
  • Brugada syndrome
  • Depolarization
  • Magnetocardiogram
  • Right-bundle branch block

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography. / Kandori, Akihiko; Miyashita, Tsuyoshi; Ogata, Kuniomi; Shimizu, Wataru; Yokokawa, Miki; Kamakura, Shiro; Miyatake, Kunio; Tsukada, Keiji; Yamada, Satsuki; Watanabe, Shigeyuki; Yamaguchi, Iwao.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 29, No. 1, 01.2006, p. 15-20.

Research output: Contribution to journalArticle

Kandori, Akihiko ; Miyashita, Tsuyoshi ; Ogata, Kuniomi ; Shimizu, Wataru ; Yokokawa, Miki ; Kamakura, Shiro ; Miyatake, Kunio ; Tsukada, Keiji ; Yamada, Satsuki ; Watanabe, Shigeyuki ; Yamaguchi, Iwao. / Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography. In: PACE - Pacing and Clinical Electrophysiology. 2006 ; Vol. 29, No. 1. pp. 15-20.
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AU - Kandori, Akihiko

AU - Miyashita, Tsuyoshi

AU - Ogata, Kuniomi

AU - Shimizu, Wataru

AU - Yokokawa, Miki

AU - Kamakura, Shiro

AU - Miyatake, Kunio

AU - Tsukada, Keiji

AU - Yamada, Satsuki

AU - Watanabe, Shigeyuki

AU - Yamaguchi, Iwao

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AB - Background: Both ventricular depolarization abnormalities (QRS complex) and repolarization ones (ST/T) are still controversial in literature. The objective of this study was to clarify the space-time variations that occur in patients carriers of Brugada syndrome using Magnetocardiography and also compare them with cases of complete right-bundle branch block (CRBBB) and individuals without any dromotropic disorder (control group). Methods and Results: Magnetocardiograms (MCGs) of Brugada syndrome patients (n = 16), CRBBB patients (n = 14), and members of a control group (n = 46) at rest were recorded. The MCGs were used to produce a whole-heart electrical-activation diagram (W-HEAD), which can visualize the spatial time-variant activation in the whole heart. In the W-HEAD pattern, three activations were located in the left ventricle, and CRBBB patients had a wide peak with about 65-ms delay on the right anterior side. While the Brugada syndrome pattern has a posteromedian left-ventricle excitation, that is half the amplitude that occurs in CRBBB patients, the electrical conduction rate to the posterosuperior septum area was low. Conclusions: The W-HEAD data made it possible to visualize space-time depolarization abnormalities. These findings suggest that the electrical conduction rate to the posterosuperior septum area in Brugada syndrome cases is low, and this low activation may be a feature of typical Brugada syndrome.

KW - Arrhythmia

KW - Brugada syndrome

KW - Depolarization

KW - Magnetocardiogram

KW - Right-bundle branch block

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