Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury

Jan T. Hachmann, Peter J. Grahn, Jonathan S. Calvert, Dina I. Drubach, Kendall H Lee, Igor A. Lavrov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is a complex and devastating condition characterized by disruption of descending, ascending, and intrinsic spinal circuitry resulting in chronic neurologic deficits. In addition to limb and trunk sensorimotor deficits, SCI can impair autonomic neurocircuitry such as the motor networks that support respiration and cough. High cervical SCI can cause complete respiratory paralysis, and even lower cervical or thoracic lesions commonly result in partial respiratory impairment. Although electrophrenic respiration can restore ventilator-independent breathing in select candidates, only a small subset of affected individuals can benefit from this technology at this moment. Over the past decades, spinal cord stimulation has shown promise for augmentation and recovery of neurologic function including motor control, cough, and breathing. The present review discusses the challenges and potentials of spinal cord stimulation for restoring respiratory function by overcoming some of the limitations of conventional respiratory functional electrical stimulation systems.

Original languageEnglish (US)
JournalMayo Clinic Proceedings
DOIs
StateAccepted/In press - 2017

Fingerprint

Spinal Cord Injuries
Respiratory System
Respiration
Spinal Cord Stimulation
Cough
Respiratory Paralysis
Recovery of Function
Mechanical Ventilators
Neurologic Manifestations
Nervous System
Electric Stimulation
Thorax
Extremities
Technology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hachmann, J. T., Grahn, P. J., Calvert, J. S., Drubach, D. I., Lee, K. H., & Lavrov, I. A. (Accepted/In press). Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury. Mayo Clinic Proceedings. https://doi.org/10.1016/j.mayocp.2017.04.011

Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury. / Hachmann, Jan T.; Grahn, Peter J.; Calvert, Jonathan S.; Drubach, Dina I.; Lee, Kendall H; Lavrov, Igor A.

In: Mayo Clinic Proceedings, 2017.

Research output: Contribution to journalArticle

Hachmann, Jan T. ; Grahn, Peter J. ; Calvert, Jonathan S. ; Drubach, Dina I. ; Lee, Kendall H ; Lavrov, Igor A. / Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury. In: Mayo Clinic Proceedings. 2017.
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