Electrical activity modulates growth cone guidance by diffusible factors

Guo Li Ming, John R Henley, Marc Tessier-Lavigne, Hong Jun Song, Mu Ming Poo

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

Original languageEnglish (US)
Pages (from-to)441-452
Number of pages12
JournalNeuron
Volume29
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Growth Cones
Electric Stimulation
Myelin-Associated Glycoprotein
Neurons
Nerve Regeneration
Myelin Sheath
Xenopus
Cues
Membranes
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ming, G. L., Henley, J. R., Tessier-Lavigne, M., Song, H. J., & Poo, M. M. (2001). Electrical activity modulates growth cone guidance by diffusible factors. Neuron, 29(2), 441-452. https://doi.org/10.1016/S0896-6273(01)00217-3

Electrical activity modulates growth cone guidance by diffusible factors. / Ming, Guo Li; Henley, John R; Tessier-Lavigne, Marc; Song, Hong Jun; Poo, Mu Ming.

In: Neuron, Vol. 29, No. 2, 2001, p. 441-452.

Research output: Contribution to journalArticle

Ming, GL, Henley, JR, Tessier-Lavigne, M, Song, HJ & Poo, MM 2001, 'Electrical activity modulates growth cone guidance by diffusible factors', Neuron, vol. 29, no. 2, pp. 441-452. https://doi.org/10.1016/S0896-6273(01)00217-3
Ming, Guo Li ; Henley, John R ; Tessier-Lavigne, Marc ; Song, Hong Jun ; Poo, Mu Ming. / Electrical activity modulates growth cone guidance by diffusible factors. In: Neuron. 2001 ; Vol. 29, No. 2. pp. 441-452.
@article{c73ca3ff765343fcb1eb24706d24fdb8,
title = "Electrical activity modulates growth cone guidance by diffusible factors",
abstract = "Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.",
author = "Ming, {Guo Li} and Henley, {John R} and Marc Tessier-Lavigne and Song, {Hong Jun} and Poo, {Mu Ming}",
year = "2001",
doi = "10.1016/S0896-6273(01)00217-3",
language = "English (US)",
volume = "29",
pages = "441--452",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Electrical activity modulates growth cone guidance by diffusible factors

AU - Ming, Guo Li

AU - Henley, John R

AU - Tessier-Lavigne, Marc

AU - Song, Hong Jun

AU - Poo, Mu Ming

PY - 2001

Y1 - 2001

N2 - Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

AB - Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

UR - http://www.scopus.com/inward/record.url?scp=0035105140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035105140&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(01)00217-3

DO - 10.1016/S0896-6273(01)00217-3

M3 - Article

C2 - 11239434

AN - SCOPUS:0035105140

VL - 29

SP - 441

EP - 452

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -