Elastase-induced saccular aneurysms in rabbits: Comparison of geometric features with those of human aneurysms

J. G. Short, N. H. Fujiwara, W. F. Marx, G. A. Helm, H. J. Cloft, David F Kallmes

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The development of more effective intracranial aneurysm therapy depends on the ability to test various intravascular occlusion devices and techniques in preclinical animal models. This requires the creation of experimental aneurysms, which, ideally, should mimic the size and geometric features of human intracranial aneurysms. The purpose of this study was to characterize the morphologic features of elastase-induced saccular aneurysms in rabbits to determine whether the morphology of such aneurysms mimics that of human intracranial aneurysms. METHODS: Elastase-induced saccular aneurysms were created in 40 New Zealand white rabbits. Intravenous digital subtraction angiography was performed 14 days after surgery. Relative to an external sizing device, the following dimensions were determined: aneurysm dome (height and width), aneurysm neck diameter, and parent artery diameter. Based on maximal diameter, aneurysms were categorized as small (2.0-4.9 mm), medium-sized (5.0-9.9 mm), or large (10-16 mm), and as narrow-necked (<4.0 mm neck width) or wide-necked (>4.0 mm neck width). Mean dome-neck ratio was calculated and compared with that of human aneurysms. RESULTS: All aneurysm cavities were angiographically patent. Widths of the cavities ranged from 2.5 to 7.1 mm (mean, 4.1 ± 1.2 mm); heights ranged from 3.0 to 15.6 mm (mean, 8.8 ± 2.6 mm). Three (7.5%) of 40 aneurysms were small, 20 (50%) were medium-sized, and 17 (42.5%) were large. Twenty-two (55%) of 40 aneurysms were small-necked, and 18 (45%) were wide-necked. Mean dome-neck ratio was 1.13 ± 0.54. Mean parent artery diameter was 4.3 ± 1.4 mm. CONCLUSION: Saccular aneurysms of sizes similar to that of human intracranial aneurysms were reliably created using a simple method of vessel ligation and elastase injury. Neck sizes varied with both large and small-necked aneurysms created.

Original languageEnglish (US)
Pages (from-to)1833-1837
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume22
Issue number10
StatePublished - 2001
Externally publishedYes

Fingerprint

Pancreatic Elastase
Aneurysm
Rabbits
Intracranial Aneurysm
Neck
Arteries
Equipment and Supplies
Digital Subtraction Angiography
Ambulatory Surgical Procedures
Ligation
Animal Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Elastase-induced saccular aneurysms in rabbits : Comparison of geometric features with those of human aneurysms. / Short, J. G.; Fujiwara, N. H.; Marx, W. F.; Helm, G. A.; Cloft, H. J.; Kallmes, David F.

In: American Journal of Neuroradiology, Vol. 22, No. 10, 2001, p. 1833-1837.

Research output: Contribution to journalArticle

Short, J. G. ; Fujiwara, N. H. ; Marx, W. F. ; Helm, G. A. ; Cloft, H. J. ; Kallmes, David F. / Elastase-induced saccular aneurysms in rabbits : Comparison of geometric features with those of human aneurysms. In: American Journal of Neuroradiology. 2001 ; Vol. 22, No. 10. pp. 1833-1837.
@article{80a5e76215c14f21a6545ca2c7a7bc8a,
title = "Elastase-induced saccular aneurysms in rabbits: Comparison of geometric features with those of human aneurysms",
abstract = "BACKGROUND AND PURPOSE: The development of more effective intracranial aneurysm therapy depends on the ability to test various intravascular occlusion devices and techniques in preclinical animal models. This requires the creation of experimental aneurysms, which, ideally, should mimic the size and geometric features of human intracranial aneurysms. The purpose of this study was to characterize the morphologic features of elastase-induced saccular aneurysms in rabbits to determine whether the morphology of such aneurysms mimics that of human intracranial aneurysms. METHODS: Elastase-induced saccular aneurysms were created in 40 New Zealand white rabbits. Intravenous digital subtraction angiography was performed 14 days after surgery. Relative to an external sizing device, the following dimensions were determined: aneurysm dome (height and width), aneurysm neck diameter, and parent artery diameter. Based on maximal diameter, aneurysms were categorized as small (2.0-4.9 mm), medium-sized (5.0-9.9 mm), or large (10-16 mm), and as narrow-necked (<4.0 mm neck width) or wide-necked (>4.0 mm neck width). Mean dome-neck ratio was calculated and compared with that of human aneurysms. RESULTS: All aneurysm cavities were angiographically patent. Widths of the cavities ranged from 2.5 to 7.1 mm (mean, 4.1 ± 1.2 mm); heights ranged from 3.0 to 15.6 mm (mean, 8.8 ± 2.6 mm). Three (7.5{\%}) of 40 aneurysms were small, 20 (50{\%}) were medium-sized, and 17 (42.5{\%}) were large. Twenty-two (55{\%}) of 40 aneurysms were small-necked, and 18 (45{\%}) were wide-necked. Mean dome-neck ratio was 1.13 ± 0.54. Mean parent artery diameter was 4.3 ± 1.4 mm. CONCLUSION: Saccular aneurysms of sizes similar to that of human intracranial aneurysms were reliably created using a simple method of vessel ligation and elastase injury. Neck sizes varied with both large and small-necked aneurysms created.",
author = "Short, {J. G.} and Fujiwara, {N. H.} and Marx, {W. F.} and Helm, {G. A.} and Cloft, {H. J.} and Kallmes, {David F}",
year = "2001",
language = "English (US)",
volume = "22",
pages = "1833--1837",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "10",

}

TY - JOUR

T1 - Elastase-induced saccular aneurysms in rabbits

T2 - Comparison of geometric features with those of human aneurysms

AU - Short, J. G.

AU - Fujiwara, N. H.

AU - Marx, W. F.

AU - Helm, G. A.

AU - Cloft, H. J.

AU - Kallmes, David F

PY - 2001

Y1 - 2001

N2 - BACKGROUND AND PURPOSE: The development of more effective intracranial aneurysm therapy depends on the ability to test various intravascular occlusion devices and techniques in preclinical animal models. This requires the creation of experimental aneurysms, which, ideally, should mimic the size and geometric features of human intracranial aneurysms. The purpose of this study was to characterize the morphologic features of elastase-induced saccular aneurysms in rabbits to determine whether the morphology of such aneurysms mimics that of human intracranial aneurysms. METHODS: Elastase-induced saccular aneurysms were created in 40 New Zealand white rabbits. Intravenous digital subtraction angiography was performed 14 days after surgery. Relative to an external sizing device, the following dimensions were determined: aneurysm dome (height and width), aneurysm neck diameter, and parent artery diameter. Based on maximal diameter, aneurysms were categorized as small (2.0-4.9 mm), medium-sized (5.0-9.9 mm), or large (10-16 mm), and as narrow-necked (<4.0 mm neck width) or wide-necked (>4.0 mm neck width). Mean dome-neck ratio was calculated and compared with that of human aneurysms. RESULTS: All aneurysm cavities were angiographically patent. Widths of the cavities ranged from 2.5 to 7.1 mm (mean, 4.1 ± 1.2 mm); heights ranged from 3.0 to 15.6 mm (mean, 8.8 ± 2.6 mm). Three (7.5%) of 40 aneurysms were small, 20 (50%) were medium-sized, and 17 (42.5%) were large. Twenty-two (55%) of 40 aneurysms were small-necked, and 18 (45%) were wide-necked. Mean dome-neck ratio was 1.13 ± 0.54. Mean parent artery diameter was 4.3 ± 1.4 mm. CONCLUSION: Saccular aneurysms of sizes similar to that of human intracranial aneurysms were reliably created using a simple method of vessel ligation and elastase injury. Neck sizes varied with both large and small-necked aneurysms created.

AB - BACKGROUND AND PURPOSE: The development of more effective intracranial aneurysm therapy depends on the ability to test various intravascular occlusion devices and techniques in preclinical animal models. This requires the creation of experimental aneurysms, which, ideally, should mimic the size and geometric features of human intracranial aneurysms. The purpose of this study was to characterize the morphologic features of elastase-induced saccular aneurysms in rabbits to determine whether the morphology of such aneurysms mimics that of human intracranial aneurysms. METHODS: Elastase-induced saccular aneurysms were created in 40 New Zealand white rabbits. Intravenous digital subtraction angiography was performed 14 days after surgery. Relative to an external sizing device, the following dimensions were determined: aneurysm dome (height and width), aneurysm neck diameter, and parent artery diameter. Based on maximal diameter, aneurysms were categorized as small (2.0-4.9 mm), medium-sized (5.0-9.9 mm), or large (10-16 mm), and as narrow-necked (<4.0 mm neck width) or wide-necked (>4.0 mm neck width). Mean dome-neck ratio was calculated and compared with that of human aneurysms. RESULTS: All aneurysm cavities were angiographically patent. Widths of the cavities ranged from 2.5 to 7.1 mm (mean, 4.1 ± 1.2 mm); heights ranged from 3.0 to 15.6 mm (mean, 8.8 ± 2.6 mm). Three (7.5%) of 40 aneurysms were small, 20 (50%) were medium-sized, and 17 (42.5%) were large. Twenty-two (55%) of 40 aneurysms were small-necked, and 18 (45%) were wide-necked. Mean dome-neck ratio was 1.13 ± 0.54. Mean parent artery diameter was 4.3 ± 1.4 mm. CONCLUSION: Saccular aneurysms of sizes similar to that of human intracranial aneurysms were reliably created using a simple method of vessel ligation and elastase injury. Neck sizes varied with both large and small-necked aneurysms created.

UR - http://www.scopus.com/inward/record.url?scp=0035181951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035181951&partnerID=8YFLogxK

M3 - Article

C2 - 11733310

AN - SCOPUS:0035181951

VL - 22

SP - 1833

EP - 1837

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 10

ER -